The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells

The minimal vertebrate telomerase enzyme is composed of a protein component (telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA, TR). Expression of these two subunits is sufficient to reconstitute telomerase activity in vitro, while the formation of a holoenzyme comprising...

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Detalles Bibliográficos
Autores principales: Trapp-Fragnet, Laetitia, Marie-Egyptienne, Delphine T., Fakhoury, Johans, Rasschaert, Denis, Autexier, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275662/
https://www.ncbi.nlm.nih.gov/pubmed/22941205
http://dx.doi.org/10.2478/s11658-012-0031-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275662/
https://www.ncbi.nlm.nih.gov/pubmed/22941205
http://dx.doi.org/10.2478/s11658-012-0031-6

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