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Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhi...

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Detalles Bibliográficos
Autores principales:	Hublarova, Pavla, Greplova, Kristina, Holcakova, Jitka, Vojtesek, Borivoj, Hrstka, Roman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SP Versita 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275699/ https://www.ncbi.nlm.nih.gov/pubmed/20526748 http://dx.doi.org/10.2478/s11658-010-0021-5

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