High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, d...

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Detalles Bibliográficos
Autores principales: Hirokawa, Yoshifumi S., Takagi, Akimitsu, Uchida, Katsunori, Kozuka, Yuji, Yoneda, Misao, Watanabe, Masatoshi, Shiraishi, Taizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275712/
https://www.ncbi.nlm.nih.gov/pubmed/17318295
http://dx.doi.org/10.2478/s11658-007-0009-y
Descripción
Sumario:In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

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