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Prion protein and its role in signal transduction
Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (P...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SP Versita
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275729/ https://www.ncbi.nlm.nih.gov/pubmed/23479001 http://dx.doi.org/10.2478/s11658-013-0085-0 |
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author | Didonna, Alessandro |
author_facet | Didonna, Alessandro |
author_sort | Didonna, Alessandro |
collection | PubMed |
description | Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (PrP(C)) into new prion molecules by acting as a template. Since Stanley B. Prusiner proposed the “protein-only” hypothesis for the first time, considerable effort has been put into defining the role played by PrP(C) in neurons. However, its physiological function remains unclear. This review summarizes the major findings that support the involvement of PrP(C) in signal transduction. |
format | Online Article Text |
id | pubmed-6275729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SP Versita |
record_format | MEDLINE/PubMed |
spelling | pubmed-62757292018-12-10 Prion protein and its role in signal transduction Didonna, Alessandro Cell Mol Biol Lett Mini Review Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (PrP(C)) into new prion molecules by acting as a template. Since Stanley B. Prusiner proposed the “protein-only” hypothesis for the first time, considerable effort has been put into defining the role played by PrP(C) in neurons. However, its physiological function remains unclear. This review summarizes the major findings that support the involvement of PrP(C) in signal transduction. SP Versita 2013-03-11 /pmc/articles/PMC6275729/ /pubmed/23479001 http://dx.doi.org/10.2478/s11658-013-0085-0 Text en © Versita Warsaw and Springer-Verlag Wien 2013 |
spellingShingle | Mini Review Didonna, Alessandro Prion protein and its role in signal transduction |
title | Prion protein and its role in signal transduction |
title_full | Prion protein and its role in signal transduction |
title_fullStr | Prion protein and its role in signal transduction |
title_full_unstemmed | Prion protein and its role in signal transduction |
title_short | Prion protein and its role in signal transduction |
title_sort | prion protein and its role in signal transduction |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275729/ https://www.ncbi.nlm.nih.gov/pubmed/23479001 http://dx.doi.org/10.2478/s11658-013-0085-0 |
work_keys_str_mv | AT didonnaalessandro prionproteinanditsroleinsignaltransduction |