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Prion protein and its role in signal transduction

Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (P...

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Detalles Bibliográficos
Autor principal: Didonna, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275729/
https://www.ncbi.nlm.nih.gov/pubmed/23479001
http://dx.doi.org/10.2478/s11658-013-0085-0
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author Didonna, Alessandro
author_facet Didonna, Alessandro
author_sort Didonna, Alessandro
collection PubMed
description Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (PrP(C)) into new prion molecules by acting as a template. Since Stanley B. Prusiner proposed the “protein-only” hypothesis for the first time, considerable effort has been put into defining the role played by PrP(C) in neurons. However, its physiological function remains unclear. This review summarizes the major findings that support the involvement of PrP(C) in signal transduction.
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spelling pubmed-62757292018-12-10 Prion protein and its role in signal transduction Didonna, Alessandro Cell Mol Biol Lett Mini Review Prion diseases are a class of fatal neurodegenerative disorders that can be sporadic, genetic or iatrogenic. They are characterized by the unique nature of their etiologic agent: prions (PrP(Sc)). A prion is an infectious protein with the ability to convert the host-encoded cellular prion protein (PrP(C)) into new prion molecules by acting as a template. Since Stanley B. Prusiner proposed the “protein-only” hypothesis for the first time, considerable effort has been put into defining the role played by PrP(C) in neurons. However, its physiological function remains unclear. This review summarizes the major findings that support the involvement of PrP(C) in signal transduction. SP Versita 2013-03-11 /pmc/articles/PMC6275729/ /pubmed/23479001 http://dx.doi.org/10.2478/s11658-013-0085-0 Text en © Versita Warsaw and Springer-Verlag Wien 2013
spellingShingle Mini Review
Didonna, Alessandro
Prion protein and its role in signal transduction
title Prion protein and its role in signal transduction
title_full Prion protein and its role in signal transduction
title_fullStr Prion protein and its role in signal transduction
title_full_unstemmed Prion protein and its role in signal transduction
title_short Prion protein and its role in signal transduction
title_sort prion protein and its role in signal transduction
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275729/
https://www.ncbi.nlm.nih.gov/pubmed/23479001
http://dx.doi.org/10.2478/s11658-013-0085-0
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