Autophagy favors Brucella melitensis survival in infected macrophages

This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker p...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Fei, Zhang, Hui, Chen, Chuangfu, Hu, Shengwei, Wang, Yuanzhi, Qiao, Jun, Ren, Yan, Zhang, Ke, Wang, Yong, Du, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275789/
https://www.ncbi.nlm.nih.gov/pubmed/22367856
http://dx.doi.org/10.2478/s11658-012-0009-4
Descripción
Sumario:This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.

Ejemplares similares