Cargando…

Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment

Immunotherapy has revolutionized the treatment of non‐small cell lung cancer; however, its role in the treatment response of lung brain metastasis is unknown. Understanding immunotherapy activity in the central nervous system is important in order to avoid additional toxicity, such as that associate...

Descripción completa

Detalles Bibliográficos
Autores principales: Melian, Marcos, Lorente, David, Aparici, Fernando, Juan, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275812/
https://www.ncbi.nlm.nih.gov/pubmed/30276979
http://dx.doi.org/10.1111/1759-7714.12873
_version_ 1783377883823079424
author Melian, Marcos
Lorente, David
Aparici, Fernando
Juan, Oscar
author_facet Melian, Marcos
Lorente, David
Aparici, Fernando
Juan, Oscar
author_sort Melian, Marcos
collection PubMed
description Immunotherapy has revolutionized the treatment of non‐small cell lung cancer; however, its role in the treatment response of lung brain metastasis is unknown. Understanding immunotherapy activity in the central nervous system is important in order to avoid additional toxicity, such as that associated with the use of cerebral radiotherapy. We present two cases with clinical and radiological progression with increases in size and perilesional edema of brain lesions after treatment with a combination of ipilimumab and nivolumab. The increasing use of immunotherapy in lung cancer requires increased knowledge of new patterns of radiological response, such as pseudoprogression.
format Online
Article
Text
id pubmed-6275812
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley & Sons Australia, Ltd
record_format MEDLINE/PubMed
spelling pubmed-62758122018-12-06 Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment Melian, Marcos Lorente, David Aparici, Fernando Juan, Oscar Thorac Cancer Case Reports Immunotherapy has revolutionized the treatment of non‐small cell lung cancer; however, its role in the treatment response of lung brain metastasis is unknown. Understanding immunotherapy activity in the central nervous system is important in order to avoid additional toxicity, such as that associated with the use of cerebral radiotherapy. We present two cases with clinical and radiological progression with increases in size and perilesional edema of brain lesions after treatment with a combination of ipilimumab and nivolumab. The increasing use of immunotherapy in lung cancer requires increased knowledge of new patterns of radiological response, such as pseudoprogression. John Wiley & Sons Australia, Ltd 2018-10-01 2018-12 /pmc/articles/PMC6275812/ /pubmed/30276979 http://dx.doi.org/10.1111/1759-7714.12873 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Melian, Marcos
Lorente, David
Aparici, Fernando
Juan, Oscar
Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title_full Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title_fullStr Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title_full_unstemmed Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title_short Lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
title_sort lung brain metastasis pseudoprogression after nivolumab and ipilimumab combination treatment
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275812/
https://www.ncbi.nlm.nih.gov/pubmed/30276979
http://dx.doi.org/10.1111/1759-7714.12873
work_keys_str_mv AT melianmarcos lungbrainmetastasispseudoprogressionafternivolumabandipilimumabcombinationtreatment
AT lorentedavid lungbrainmetastasispseudoprogressionafternivolumabandipilimumabcombinationtreatment
AT aparicifernando lungbrainmetastasispseudoprogressionafternivolumabandipilimumabcombinationtreatment
AT juanoscar lungbrainmetastasispseudoprogressionafternivolumabandipilimumabcombinationtreatment