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Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

Spontaneous regression (SR) of cancer implies the partial or complete disappearance of malignant disease without or with adequate medical treatment. Typically, SR of cancer is a sporadic event, especially in non‐small cell lung cancer (NSCLC). Although the underlying mechanism of SR remains unknown,...

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Detalles Bibliográficos
Autores principales: Matsui, Takuya, Mizuno, Tetsuya, Kuroda, Hiroaki, Sakakura, Noriaki, Arimura, Takaaki, Yatabe, Yasushi, Sakao, Yukinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275820/
https://www.ncbi.nlm.nih.gov/pubmed/30311443
http://dx.doi.org/10.1111/1759-7714.12892
Descripción
Sumario:Spontaneous regression (SR) of cancer implies the partial or complete disappearance of malignant disease without or with adequate medical treatment. Typically, SR of cancer is a sporadic event, especially in non‐small cell lung cancer (NSCLC). Although the underlying mechanism of SR remains unknown, stimulation of an immunological response has been proposed. Herein, we report the case of a 56‐year‐old woman exhibiting SR of NSCLC with a mediastinal disease. Despite regression of the primary site after a lung biopsy, simultaneous progression of mediastinal lymph node metastasis occurred. Specimens obtained by surgical resection pathologically confirmed both primary and metastatic sites. Reportedly, primary and metastatic tumors shrink synchronously in SR of metastatic NSCLCs. Thus, the fact that the SR of NSCLC can present inconsistent development in primary and metastatic sites should be considered, and direct intervention is recommended if physicians diagnose this phenomenon.