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Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we de...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Versita
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275886/ https://www.ncbi.nlm.nih.gov/pubmed/19554268 http://dx.doi.org/10.2478/s11658-009-0018-0 |
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author | Schara, Karin Janša, Vid Šuštar, Vid Dolinar, Drago Pavlič, Janez Ivan Lokar, Maruša Kralj-Iglič, Veronika Veranič, Peter Iglič, Aleš |
author_facet | Schara, Karin Janša, Vid Šuštar, Vid Dolinar, Drago Pavlič, Janez Ivan Lokar, Maruša Kralj-Iglič, Veronika Veranič, Peter Iglič, Aleš |
author_sort | Schara, Karin |
collection | PubMed |
description | Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression of microvesicluation due to plasma-mediated attractive interaction between membranes. |
format | Online Article Text |
id | pubmed-6275886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | SP Versita |
record_format | MEDLINE/PubMed |
spelling | pubmed-62758862018-12-10 Mechanisms for the formation of membranous nanostructures in cell-to-cell communication Schara, Karin Janša, Vid Šuštar, Vid Dolinar, Drago Pavlič, Janez Ivan Lokar, Maruša Kralj-Iglič, Veronika Veranič, Peter Iglič, Aleš Cell Mol Biol Lett Review Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression of microvesicluation due to plasma-mediated attractive interaction between membranes. SP Versita 2009-06-25 /pmc/articles/PMC6275886/ /pubmed/19554268 http://dx.doi.org/10.2478/s11658-009-0018-0 Text en © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009 |
spellingShingle | Review Schara, Karin Janša, Vid Šuštar, Vid Dolinar, Drago Pavlič, Janez Ivan Lokar, Maruša Kralj-Iglič, Veronika Veranič, Peter Iglič, Aleš Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title | Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title_full | Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title_fullStr | Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title_full_unstemmed | Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title_short | Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
title_sort | mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275886/ https://www.ncbi.nlm.nih.gov/pubmed/19554268 http://dx.doi.org/10.2478/s11658-009-0018-0 |
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