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Mechanisms for the formation of membranous nanostructures in cell-to-cell communication

Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we de...

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Detalles Bibliográficos
Autores principales: Schara, Karin, Janša, Vid, Šuštar, Vid, Dolinar, Drago, Pavlič, Janez Ivan, Lokar, Maruša, Kralj-Iglič, Veronika, Veranič, Peter, Iglič, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275886/
https://www.ncbi.nlm.nih.gov/pubmed/19554268
http://dx.doi.org/10.2478/s11658-009-0018-0
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author Schara, Karin
Janša, Vid
Šuštar, Vid
Dolinar, Drago
Pavlič, Janez Ivan
Lokar, Maruša
Kralj-Iglič, Veronika
Veranič, Peter
Iglič, Aleš
author_facet Schara, Karin
Janša, Vid
Šuštar, Vid
Dolinar, Drago
Pavlič, Janez Ivan
Lokar, Maruša
Kralj-Iglič, Veronika
Veranič, Peter
Iglič, Aleš
author_sort Schara, Karin
collection PubMed
description Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression of microvesicluation due to plasma-mediated attractive interaction between membranes.
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spelling pubmed-62758862018-12-10 Mechanisms for the formation of membranous nanostructures in cell-to-cell communication Schara, Karin Janša, Vid Šuštar, Vid Dolinar, Drago Pavlič, Janez Ivan Lokar, Maruša Kralj-Iglič, Veronika Veranič, Peter Iglič, Aleš Cell Mol Biol Lett Review Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression of microvesicluation due to plasma-mediated attractive interaction between membranes. SP Versita 2009-06-25 /pmc/articles/PMC6275886/ /pubmed/19554268 http://dx.doi.org/10.2478/s11658-009-0018-0 Text en © © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009
spellingShingle Review
Schara, Karin
Janša, Vid
Šuštar, Vid
Dolinar, Drago
Pavlič, Janez Ivan
Lokar, Maruša
Kralj-Iglič, Veronika
Veranič, Peter
Iglič, Aleš
Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title_full Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title_fullStr Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title_full_unstemmed Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title_short Mechanisms for the formation of membranous nanostructures in cell-to-cell communication
title_sort mechanisms for the formation of membranous nanostructures in cell-to-cell communication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275886/
https://www.ncbi.nlm.nih.gov/pubmed/19554268
http://dx.doi.org/10.2478/s11658-009-0018-0
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