The breakdown of bilayer lipid membranes by dendrimers

The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydr...

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Detalles Bibliográficos
Autores principales: Shcharbin, Dzmitry, Drapeza, Alexander, Loban, Valeri, Lisichenok, Alexej, Bryszewska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276016/
https://www.ncbi.nlm.nih.gov/pubmed/16847568
http://dx.doi.org/10.2478/s11658-006-0018-2
Descripción
Sumario:The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.

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