Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and seque...

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Autores principales: Lima, Lyana Rodrigues Pinto, de Araújo, Nathália Alves, Guterres, Alexandro, Pilotto, José Henrique, Niel, Christian, de Paula, Vanessa Salete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276022/
https://www.ncbi.nlm.nih.gov/pubmed/30517210
http://dx.doi.org/10.1590/0074-02760180328
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author Lima, Lyana Rodrigues Pinto
de Araújo, Nathália Alves
Guterres, Alexandro
Pilotto, José Henrique
Niel, Christian
de Paula, Vanessa Salete
author_facet Lima, Lyana Rodrigues Pinto
de Araújo, Nathália Alves
Guterres, Alexandro
Pilotto, José Henrique
Niel, Christian
de Paula, Vanessa Salete
author_sort Lima, Lyana Rodrigues Pinto
collection PubMed
description BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
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spelling pubmed-62760222018-12-06 Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects Lima, Lyana Rodrigues Pinto de Araújo, Nathália Alves Guterres, Alexandro Pilotto, José Henrique Niel, Christian de Paula, Vanessa Salete Mem Inst Oswaldo Cruz Short Communication BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated. Instituto Oswaldo Cruz, Ministério da Saúde 2018-12-03 /pmc/articles/PMC6276022/ /pubmed/30517210 http://dx.doi.org/10.1590/0074-02760180328 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Lima, Lyana Rodrigues Pinto
de Araújo, Nathália Alves
Guterres, Alexandro
Pilotto, José Henrique
Niel, Christian
de Paula, Vanessa Salete
Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title_full Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title_fullStr Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title_full_unstemmed Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title_short Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
title_sort novel variants of human herpesvirus 2 from brazilian hiv-1 coinfected subjects
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276022/
https://www.ncbi.nlm.nih.gov/pubmed/30517210
http://dx.doi.org/10.1590/0074-02760180328
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