Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer

Some N‐tosylhydrazone derivatives were effectively synthesized under solvent‐free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup and easy purification of the target compounds were salient features of the present protocol,...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Zengyang, Song, Yuying, Xu, Lujia, Guo, Yukun, Zhang, Min, Li, Limei, Chen, Kai, Liu, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276103/
https://www.ncbi.nlm.nih.gov/pubmed/30524923
http://dx.doi.org/10.1002/open.201800206
_version_ 1783377948670164992
author Xie, Zengyang
Song, Yuying
Xu, Lujia
Guo, Yukun
Zhang, Min
Li, Limei
Chen, Kai
Liu, Xue
author_facet Xie, Zengyang
Song, Yuying
Xu, Lujia
Guo, Yukun
Zhang, Min
Li, Limei
Chen, Kai
Liu, Xue
author_sort Xie, Zengyang
collection PubMed
description Some N‐tosylhydrazone derivatives were effectively synthesized under solvent‐free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup and easy purification of the target compounds were salient features of the present protocol, which enables straightforward access to N‐tosylhydrazones. Among the tosylhydrazone derivatives evaluated, compound 3 l exhibits excellent apoptosis‐promoting and anticancer potential against triple‐negative breast cancer (TNBC) cell lines. This research shows that our synthesized compound 3 l may be a desirable and effective therapeutic drug against TNBC.
format Online
Article
Text
id pubmed-6276103
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-62761032018-12-06 Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer Xie, Zengyang Song, Yuying Xu, Lujia Guo, Yukun Zhang, Min Li, Limei Chen, Kai Liu, Xue ChemistryOpen Full Papers Some N‐tosylhydrazone derivatives were effectively synthesized under solvent‐free conditions by using a grinding method at room temperature. The short reaction time, clean and mild process with simple workup and easy purification of the target compounds were salient features of the present protocol, which enables straightforward access to N‐tosylhydrazones. Among the tosylhydrazone derivatives evaluated, compound 3 l exhibits excellent apoptosis‐promoting and anticancer potential against triple‐negative breast cancer (TNBC) cell lines. This research shows that our synthesized compound 3 l may be a desirable and effective therapeutic drug against TNBC. John Wiley and Sons Inc. 2018-11-21 /pmc/articles/PMC6276103/ /pubmed/30524923 http://dx.doi.org/10.1002/open.201800206 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Xie, Zengyang
Song, Yuying
Xu, Lujia
Guo, Yukun
Zhang, Min
Li, Limei
Chen, Kai
Liu, Xue
Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title_full Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title_fullStr Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title_full_unstemmed Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title_short Rapid Synthesis of N‐Tosylhydrazones under Solvent‐Free Conditions and Their Potential Application Against Human Triple‐Negative Breast Cancer
title_sort rapid synthesis of n‐tosylhydrazones under solvent‐free conditions and their potential application against human triple‐negative breast cancer
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276103/
https://www.ncbi.nlm.nih.gov/pubmed/30524923
http://dx.doi.org/10.1002/open.201800206
work_keys_str_mv AT xiezengyang rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT songyuying rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT xulujia rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT guoyukun rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT zhangmin rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT lilimei rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT chenkai rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer
AT liuxue rapidsynthesisofntosylhydrazonesundersolventfreeconditionsandtheirpotentialapplicationagainsthumantriplenegativebreastcancer

Ejemplares similares