Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice

BACKGROUND: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Beom Jin, Lee, Woon-Kyu, Lee, Hyun Woong, Lee, Kwan Sik, Kim, Ja Kyung, Chang, Hye Young, Lee, Jung Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164/
https://www.ncbi.nlm.nih.gov/pubmed/30509307
http://dx.doi.org/10.1186/s12964-018-0306-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164/
https://www.ncbi.nlm.nih.gov/pubmed/30509307
http://dx.doi.org/10.1186/s12964-018-0306-2

Ejemplares similares