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Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice

BACKGROUND: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carc...

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Detalles Bibliográficos
Autores principales:	Lim, Beom Jin, Lee, Woon-Kyu, Lee, Hyun Woong, Lee, Kwan Sik, Kim, Ja Kyung, Chang, Hye Young, Lee, Jung Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276164/ https://www.ncbi.nlm.nih.gov/pubmed/30509307 http://dx.doi.org/10.1186/s12964-018-0306-2

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