HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

BACKGROUND: Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and the deme...

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Detalles Bibliográficos
Autores principales: La Noce, Marcella, Paino, Francesca, Mele, Luigi, Papaccio, Gianpaolo, Regad, Tarik, Lombardi, Angela, Papaccio, Federica, Desiderio, Vincenzo, Tirino, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://www.ncbi.nlm.nih.gov/pubmed/30509303
http://dx.doi.org/10.1186/s13046-018-0978-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276256/
https://www.ncbi.nlm.nih.gov/pubmed/30509303
http://dx.doi.org/10.1186/s13046-018-0978-x

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