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Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China

Bovine viral diarrhea virus (BVDV) affects cows, pigs, sheep, goats, and other ruminants, as well as some wild animals. BVDV causes considerable economic losses every year and many countries have developed programs aimed at the eradication of this disease. The genetic diversity of BVDV in diseased g...

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Autores principales: Deng, Yu, Wang, Silu, Liu, Runxia, Hao, Guiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276411/
https://www.ncbi.nlm.nih.gov/pubmed/30581873
http://dx.doi.org/10.1155/2018/8274397
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author Deng, Yu
Wang, Silu
Liu, Runxia
Hao, Guiying
author_facet Deng, Yu
Wang, Silu
Liu, Runxia
Hao, Guiying
author_sort Deng, Yu
collection PubMed
description Bovine viral diarrhea virus (BVDV) affects cows, pigs, sheep, goats, and other ruminants, as well as some wild animals. BVDV causes considerable economic losses every year and many countries have developed programs aimed at the eradication of this disease. The genetic diversity of BVDV in diseased goats has never been described in southwestern China. Thus, in this study, we applied antigen-capture ELISA and RT-PCR to survey the infection rate of BVDV in diseased goats in this region. Our results demonstrated that the average BVDV infection rate in goats was 17.51%, with all positive samples indicating infection by BVDV-1 and not BVDV-2, BVDV-3, or Border disease virus. The molecular characteristics of the 5′-untranslated region (5′-UTR) of BVDV-1 were recognized as belonging predominantly to the BVDV-1a, 1b, 1c, 1m, and 1p subtypes. BVDV-1b and 1m were the most abundant subtypes identified in this region, similar to the BVDV epidemics in cattle in other regions of China. This is the first study that describes the genetic characterization of BVDV in sick goats from southwestern China and is important for future studies and control programs.
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spelling pubmed-62764112018-12-23 Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China Deng, Yu Wang, Silu Liu, Runxia Hao, Guiying J Vet Med Research Article Bovine viral diarrhea virus (BVDV) affects cows, pigs, sheep, goats, and other ruminants, as well as some wild animals. BVDV causes considerable economic losses every year and many countries have developed programs aimed at the eradication of this disease. The genetic diversity of BVDV in diseased goats has never been described in southwestern China. Thus, in this study, we applied antigen-capture ELISA and RT-PCR to survey the infection rate of BVDV in diseased goats in this region. Our results demonstrated that the average BVDV infection rate in goats was 17.51%, with all positive samples indicating infection by BVDV-1 and not BVDV-2, BVDV-3, or Border disease virus. The molecular characteristics of the 5′-untranslated region (5′-UTR) of BVDV-1 were recognized as belonging predominantly to the BVDV-1a, 1b, 1c, 1m, and 1p subtypes. BVDV-1b and 1m were the most abundant subtypes identified in this region, similar to the BVDV epidemics in cattle in other regions of China. This is the first study that describes the genetic characterization of BVDV in sick goats from southwestern China and is important for future studies and control programs. Hindawi 2018-11-18 /pmc/articles/PMC6276411/ /pubmed/30581873 http://dx.doi.org/10.1155/2018/8274397 Text en Copyright © 2018 Yu Deng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Deng, Yu
Wang, Silu
Liu, Runxia
Hao, Guiying
Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title_full Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title_fullStr Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title_full_unstemmed Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title_short Genetic Diversity of Bovine Viral Diarrhea Virus Infection in Goats in Southwestern China
title_sort genetic diversity of bovine viral diarrhea virus infection in goats in southwestern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276411/
https://www.ncbi.nlm.nih.gov/pubmed/30581873
http://dx.doi.org/10.1155/2018/8274397
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