Cargando…
A protocol developing, disseminating and implementing a core outcome set for infertility
STUDY QUESTIONS: We aim to produce, disseminate and implement a core outcome set for future infertility research. WHAT IS KNOWN ALREADY: Randomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes, which are often defined and measured in different ways...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276643/ https://www.ncbi.nlm.nih.gov/pubmed/30895248 http://dx.doi.org/10.1093/hropen/hoy007 |
_version_ | 1783378049859846144 |
---|---|
author | Duffy, J M N Bhattacharya, S Curtis, C Evers, J L H Farquharson, R G Franik, S Khalaf, Y Legro, R S Lensen, S Mol, B W Niederberger, C Ng, E H Y Repping, S Strandell, A Torrance, H L Vail, A van Wely, M Vuong, N L Wang, A Y Wang, R Wilkinson, J Youssef, M A Farquhar, C M |
author_facet | Duffy, J M N Bhattacharya, S Curtis, C Evers, J L H Farquharson, R G Franik, S Khalaf, Y Legro, R S Lensen, S Mol, B W Niederberger, C Ng, E H Y Repping, S Strandell, A Torrance, H L Vail, A van Wely, M Vuong, N L Wang, A Y Wang, R Wilkinson, J Youssef, M A Farquhar, C M |
author_sort | Duffy, J M N |
collection | PubMed |
description | STUDY QUESTIONS: We aim to produce, disseminate and implement a core outcome set for future infertility research. WHAT IS KNOWN ALREADY: Randomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes, which are often defined and measured in different ways. Such variation contributes to an inability to compare, contrast and combine results of individual RCTs. The development of a core outcome set will ensure outcomes important to key stakeholders are consistently collected and reported across future infertility research. STUDY DESIGN, SIZE, DURATION: This is a consensus study using the modified Delphi method. All stakeholders, including healthcare professionals, allied healthcare professionals, researchers and people with lived experience of infertility will be invited to participate. PARTICIPANTS/MATERIALS, SETTING, METHODS: An international steering group, including people with lived experience of infertility, healthcare professionals, allied healthcare professionals and researchers, has been formed to guide the development of this core outcome set. Potential core outcomes have been identified through a comprehensive literature review of RCTs evaluating treatments for infertility and will be entered into a modified Delphi method. Participants will be asked to score potential core outcomes on a nine-point Likert scale anchored between one (not important) and nine (critical). Repeated reflection and rescoring should promote convergence towards consensus ‘core’ outcomes. We will establish standardized definitions and recommend high-quality measurement instruments for individual core outcomes. STUDY FUNDING/COMPETING INTEREST(S): This project is funded by the Royal Society of New Zealand Catalyst Fund (3712235). BWM reports consultancy fees from Guerbet, Merck, and ObsEva. R.S.L. reports consultancy fees from Abbvie, Bayer, Fractyl and Ogeda and research sponsorship from Ferring. S.B. is the Editor-in-Chief of Human Reproduction Open. The remaining authors declare no competing interests. |
format | Online Article Text |
id | pubmed-6276643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62766432019-03-20 A protocol developing, disseminating and implementing a core outcome set for infertility Duffy, J M N Bhattacharya, S Curtis, C Evers, J L H Farquharson, R G Franik, S Khalaf, Y Legro, R S Lensen, S Mol, B W Niederberger, C Ng, E H Y Repping, S Strandell, A Torrance, H L Vail, A van Wely, M Vuong, N L Wang, A Y Wang, R Wilkinson, J Youssef, M A Farquhar, C M Hum Reprod Open Protocol STUDY QUESTIONS: We aim to produce, disseminate and implement a core outcome set for future infertility research. WHAT IS KNOWN ALREADY: Randomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes, which are often defined and measured in different ways. Such variation contributes to an inability to compare, contrast and combine results of individual RCTs. The development of a core outcome set will ensure outcomes important to key stakeholders are consistently collected and reported across future infertility research. STUDY DESIGN, SIZE, DURATION: This is a consensus study using the modified Delphi method. All stakeholders, including healthcare professionals, allied healthcare professionals, researchers and people with lived experience of infertility will be invited to participate. PARTICIPANTS/MATERIALS, SETTING, METHODS: An international steering group, including people with lived experience of infertility, healthcare professionals, allied healthcare professionals and researchers, has been formed to guide the development of this core outcome set. Potential core outcomes have been identified through a comprehensive literature review of RCTs evaluating treatments for infertility and will be entered into a modified Delphi method. Participants will be asked to score potential core outcomes on a nine-point Likert scale anchored between one (not important) and nine (critical). Repeated reflection and rescoring should promote convergence towards consensus ‘core’ outcomes. We will establish standardized definitions and recommend high-quality measurement instruments for individual core outcomes. STUDY FUNDING/COMPETING INTEREST(S): This project is funded by the Royal Society of New Zealand Catalyst Fund (3712235). BWM reports consultancy fees from Guerbet, Merck, and ObsEva. R.S.L. reports consultancy fees from Abbvie, Bayer, Fractyl and Ogeda and research sponsorship from Ferring. S.B. is the Editor-in-Chief of Human Reproduction Open. The remaining authors declare no competing interests. Oxford University Press 2018-06-15 /pmc/articles/PMC6276643/ /pubmed/30895248 http://dx.doi.org/10.1093/hropen/hoy007 Text en © The Author(s) 2018. Published byOxford University Press on behalf of the European Society of Human Reproduction and Embryology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Protocol Duffy, J M N Bhattacharya, S Curtis, C Evers, J L H Farquharson, R G Franik, S Khalaf, Y Legro, R S Lensen, S Mol, B W Niederberger, C Ng, E H Y Repping, S Strandell, A Torrance, H L Vail, A van Wely, M Vuong, N L Wang, A Y Wang, R Wilkinson, J Youssef, M A Farquhar, C M A protocol developing, disseminating and implementing a core outcome set for infertility |
title | A protocol developing, disseminating and implementing a core outcome set for infertility |
title_full | A protocol developing, disseminating and implementing a core outcome set for infertility |
title_fullStr | A protocol developing, disseminating and implementing a core outcome set for infertility |
title_full_unstemmed | A protocol developing, disseminating and implementing a core outcome set for infertility |
title_short | A protocol developing, disseminating and implementing a core outcome set for infertility |
title_sort | protocol developing, disseminating and implementing a core outcome set for infertility |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276643/ https://www.ncbi.nlm.nih.gov/pubmed/30895248 http://dx.doi.org/10.1093/hropen/hoy007 |
work_keys_str_mv | AT duffyjmn aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT bhattacharyas aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT curtisc aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT eversjlh aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT farquharsonrg aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT franiks aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT khalafy aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT legrors aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT lensens aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT molbw aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT niederbergerc aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT ngehy aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT reppings aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT strandella aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT torrancehl aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vaila aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vanwelym aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vuongnl aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wangay aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wangr aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wilkinsonj aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT youssefma aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT farquharcm aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT aprotocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT duffyjmn protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT bhattacharyas protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT curtisc protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT eversjlh protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT farquharsonrg protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT franiks protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT khalafy protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT legrors protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT lensens protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT molbw protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT niederbergerc protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT ngehy protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT reppings protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT strandella protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT torrancehl protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vaila protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vanwelym protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT vuongnl protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wangay protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wangr protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT wilkinsonj protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT youssefma protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT farquharcm protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility AT protocoldevelopingdisseminatingandimplementingacoreoutcomesetforinfertility |