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The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran

PURPOSE: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran. METHODS: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March...

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Autores principales: Medghalchi, Abdolreza, Akbari, Mitra, Alizadeh, Yousef, Moghadam, Reza Soltani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276727/
https://www.ncbi.nlm.nih.gov/pubmed/30555970
http://dx.doi.org/10.1016/j.joco.2018.07.001
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author Medghalchi, Abdolreza
Akbari, Mitra
Alizadeh, Yousef
Moghadam, Reza Soltani
author_facet Medghalchi, Abdolreza
Akbari, Mitra
Alizadeh, Yousef
Moghadam, Reza Soltani
author_sort Medghalchi, Abdolreza
collection PubMed
description PURPOSE: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran. METHODS: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded. The activity of ophthalmopathy was scored according to the clinical activity score (CAS). RESULTS: TED was diagnosed in 103 patients with a mean age of 42.1 ± 13.91 years. Of those patients, 52.4% were women, and 80% had hyperthyroidism. The mean duration of TED was 36.5 ± 53.12 months. Extraocular muscle involvement (98%) and eyelid retraction (88.3%) were the most common manifestations. Per the CAS results, 86 (83.5%) patients were at stage 0, and there was a significant difference in CAS scores between male and female patients, P = 0.02. CONCLUSIONS: The characteristics of TED in patients of the studied referral center during a two-year period, including common signs and symptoms, disease duration, treatment, an activity of disease were determined. Notably, many patients in this study had orbital squeal of TED meaning that they had inactive TED. Proper management of this serious complication requires close cooperation between endocrinologists and ophthalmologists to ensure timely referrals for appropriate care.
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spelling pubmed-62767272018-12-14 The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran Medghalchi, Abdolreza Akbari, Mitra Alizadeh, Yousef Moghadam, Reza Soltani J Curr Ophthalmol Article PURPOSE: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran. METHODS: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded. The activity of ophthalmopathy was scored according to the clinical activity score (CAS). RESULTS: TED was diagnosed in 103 patients with a mean age of 42.1 ± 13.91 years. Of those patients, 52.4% were women, and 80% had hyperthyroidism. The mean duration of TED was 36.5 ± 53.12 months. Extraocular muscle involvement (98%) and eyelid retraction (88.3%) were the most common manifestations. Per the CAS results, 86 (83.5%) patients were at stage 0, and there was a significant difference in CAS scores between male and female patients, P = 0.02. CONCLUSIONS: The characteristics of TED in patients of the studied referral center during a two-year period, including common signs and symptoms, disease duration, treatment, an activity of disease were determined. Notably, many patients in this study had orbital squeal of TED meaning that they had inactive TED. Proper management of this serious complication requires close cooperation between endocrinologists and ophthalmologists to ensure timely referrals for appropriate care. Elsevier 2018-07-19 /pmc/articles/PMC6276727/ /pubmed/30555970 http://dx.doi.org/10.1016/j.joco.2018.07.001 Text en © 2018 Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Medghalchi, Abdolreza
Akbari, Mitra
Alizadeh, Yousef
Moghadam, Reza Soltani
The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title_full The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title_fullStr The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title_full_unstemmed The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title_short The epidemiological characteristics of patients with thyroid eye disease in a referral center in northern Iran
title_sort epidemiological characteristics of patients with thyroid eye disease in a referral center in northern iran
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276727/
https://www.ncbi.nlm.nih.gov/pubmed/30555970
http://dx.doi.org/10.1016/j.joco.2018.07.001
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