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Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3(+) T cell and total lymphocyte counts

OBJECTIVE: To investigate the correlation between total lymphocyte and CD3(+) T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. METHODS: A single-center, retrospective study involving 226 patients submitted to kidney tr...

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Detalles Bibliográficos
Autores principales: Machado, Fabiani Palagi, Vicari, Alessandra Rosa, Spuldaro, Fábio, de Castro, João Batista Saldanha, Manfro, Roberto Ceratti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276809/
https://www.ncbi.nlm.nih.gov/pubmed/30517367
http://dx.doi.org/10.31744/einstein_journal/2018AO4278
Descripción
Sumario:OBJECTIVE: To investigate the correlation between total lymphocyte and CD3(+) T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes. METHODS: A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3(+) T cell or total lymphocyte counts in peripheral blood. RESULTS: A total of 664 paired samples were analyzed. The Spearman's correlation coefficient was 0.416 (p<0.001) for all samples combined; the overall Kappa coefficient was 0.267 (p<0.001). Diagnostic parameters estimated based on total lymphocyte counts were also calculated using the number of CD3(+) T cells (gold standard), with a cut off of >20 cells/mm(3). CONCLUSION: Total lymphocyte and CD3(+) T cell counts in peripheral blood are not equivalent monitoring strategies in anti-thymocyte globulin therapy.