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A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy

OBJECTIVE: The objective of the study was to develop and validate a radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD). MATERIALS AND METHODS: A total of 117 consecutive patients who underwent PD were...

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Autores principales: Zhang, Wenyu, Cai, Wei, He, Baochun, Xiang, Nan, Fang, Chihua, Jia, Fucang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276820/
https://www.ncbi.nlm.nih.gov/pubmed/30568506
http://dx.doi.org/10.2147/CMAR.S185865
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author Zhang, Wenyu
Cai, Wei
He, Baochun
Xiang, Nan
Fang, Chihua
Jia, Fucang
author_facet Zhang, Wenyu
Cai, Wei
He, Baochun
Xiang, Nan
Fang, Chihua
Jia, Fucang
author_sort Zhang, Wenyu
collection PubMed
description OBJECTIVE: The objective of the study was to develop and validate a radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD). MATERIALS AND METHODS: A total of 117 consecutive patients who underwent PD were enrolled in this retrospective study. Radiomics features were extracted from portal venous phase computed tomography of the above patients. The least absolute shrinkage and selection operator logistic regression was used to construct a formula of Rad-score calculation. Then the performance of the formula was assessed with standard pancreatic Fistula Risk Score. RESULTS: The Rad-score could predict POPF with an area under the curve (AUC) of 0.8248 in the training cohort and of 0.7609 in the validation cohort. Patients who had experienced POPF generally had a statistically higher Rad-score than those who had not experienced POPF in both cohorts. The AUC of the Rad-score was statistically higher than the Fistula Risk Score for predicting POPF in both the training and validation cohort. CONCLUSION: A novel radiomics-based formula was developed and validated for predicting POPF in patients who underwent PD, which provides a new method for identifying POPF risks and may help to improve informed decision-making in the prevention of POPF at low cost.
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spelling pubmed-62768202018-12-19 A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy Zhang, Wenyu Cai, Wei He, Baochun Xiang, Nan Fang, Chihua Jia, Fucang Cancer Manag Res Original Research OBJECTIVE: The objective of the study was to develop and validate a radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD). MATERIALS AND METHODS: A total of 117 consecutive patients who underwent PD were enrolled in this retrospective study. Radiomics features were extracted from portal venous phase computed tomography of the above patients. The least absolute shrinkage and selection operator logistic regression was used to construct a formula of Rad-score calculation. Then the performance of the formula was assessed with standard pancreatic Fistula Risk Score. RESULTS: The Rad-score could predict POPF with an area under the curve (AUC) of 0.8248 in the training cohort and of 0.7609 in the validation cohort. Patients who had experienced POPF generally had a statistically higher Rad-score than those who had not experienced POPF in both cohorts. The AUC of the Rad-score was statistically higher than the Fistula Risk Score for predicting POPF in both the training and validation cohort. CONCLUSION: A novel radiomics-based formula was developed and validated for predicting POPF in patients who underwent PD, which provides a new method for identifying POPF risks and may help to improve informed decision-making in the prevention of POPF at low cost. Dove Medical Press 2018-11-28 /pmc/articles/PMC6276820/ /pubmed/30568506 http://dx.doi.org/10.2147/CMAR.S185865 Text en © 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Wenyu
Cai, Wei
He, Baochun
Xiang, Nan
Fang, Chihua
Jia, Fucang
A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title_full A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title_fullStr A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title_full_unstemmed A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title_short A radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
title_sort radiomics-based formula for the preoperative prediction of postoperative pancreatic fistula in patients with pancreaticoduodenectomy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276820/
https://www.ncbi.nlm.nih.gov/pubmed/30568506
http://dx.doi.org/10.2147/CMAR.S185865
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