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Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length

The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimu...

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Autores principales: Laisk, Triin, Kukuškina, Viktorija, Palmer, Duncan, Laber, Samantha, Chen, Chia-Yen, Ferreira, Teresa, Rahmioglu, Nilufer, Zondervan, Krina, Becker, Christian, Smoller, Jordan W, Lippincott, Margaret, Salumets, Andres, Granne, Ingrid, Seminara, Stephanie, Neale, Benjamin, Mägi, Reedik, Lindgren, Cecilia M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276838/
https://www.ncbi.nlm.nih.gov/pubmed/30202859
http://dx.doi.org/10.1093/hmg/ddy317
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author Laisk, Triin
Kukuškina, Viktorija
Palmer, Duncan
Laber, Samantha
Chen, Chia-Yen
Ferreira, Teresa
Rahmioglu, Nilufer
Zondervan, Krina
Becker, Christian
Smoller, Jordan W
Lippincott, Margaret
Salumets, Andres
Granne, Ingrid
Seminara, Stephanie
Neale, Benjamin
Mägi, Reedik
Lindgren, Cecilia M
author_facet Laisk, Triin
Kukuškina, Viktorija
Palmer, Duncan
Laber, Samantha
Chen, Chia-Yen
Ferreira, Teresa
Rahmioglu, Nilufer
Zondervan, Krina
Becker, Christian
Smoller, Jordan W
Lippincott, Margaret
Salumets, Andres
Granne, Ingrid
Seminara, Stephanie
Neale, Benjamin
Mägi, Reedik
Lindgren, Cecilia M
author_sort Laisk, Triin
collection PubMed
description The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.
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spelling pubmed-62768382018-12-11 Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length Laisk, Triin Kukuškina, Viktorija Palmer, Duncan Laber, Samantha Chen, Chia-Yen Ferreira, Teresa Rahmioglu, Nilufer Zondervan, Krina Becker, Christian Smoller, Jordan W Lippincott, Margaret Salumets, Andres Granne, Ingrid Seminara, Stephanie Neale, Benjamin Mägi, Reedik Lindgren, Cecilia M Hum Mol Genet Association Studies Article The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2. Oxford University Press 2018-12-15 2018-09-07 /pmc/articles/PMC6276838/ /pubmed/30202859 http://dx.doi.org/10.1093/hmg/ddy317 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Association Studies Article
Laisk, Triin
Kukuškina, Viktorija
Palmer, Duncan
Laber, Samantha
Chen, Chia-Yen
Ferreira, Teresa
Rahmioglu, Nilufer
Zondervan, Krina
Becker, Christian
Smoller, Jordan W
Lippincott, Margaret
Salumets, Andres
Granne, Ingrid
Seminara, Stephanie
Neale, Benjamin
Mägi, Reedik
Lindgren, Cecilia M
Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title_full Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title_fullStr Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title_full_unstemmed Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title_short Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
title_sort large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
topic Association Studies Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276838/
https://www.ncbi.nlm.nih.gov/pubmed/30202859
http://dx.doi.org/10.1093/hmg/ddy317
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