Ykt6 mediates autophagosome-vacuole fusion

Studying the mechanism of autophagosome-vacuole fusion has proven difficult in live yeast cells. Developing a novel in vitro fusion assay, we identified Ykt6 as the missing R-SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) in this process and pinpoint the place of actio...

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Detalles Bibliográficos
Autores principales: Bas, Levent, Papinski, Daniel, Kraft, Claudine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276844/
https://www.ncbi.nlm.nih.gov/pubmed/30525099
http://dx.doi.org/10.1080/23723556.2018.1526006
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author Bas, Levent
Papinski, Daniel
Kraft, Claudine
author_facet Bas, Levent
Papinski, Daniel
Kraft, Claudine
author_sort Bas, Levent
collection PubMed
description Studying the mechanism of autophagosome-vacuole fusion has proven difficult in live yeast cells. Developing a novel in vitro fusion assay, we identified Ykt6 as the missing R-SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) in this process and pinpoint the place of action of all four SNAREs involved. Parallel studies have confirmed our findings in other organisms.
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spelling pubmed-62768442019-10-04 Ykt6 mediates autophagosome-vacuole fusion Bas, Levent Papinski, Daniel Kraft, Claudine Mol Cell Oncol Commentary Studying the mechanism of autophagosome-vacuole fusion has proven difficult in live yeast cells. Developing a novel in vitro fusion assay, we identified Ykt6 as the missing R-SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) in this process and pinpoint the place of action of all four SNAREs involved. Parallel studies have confirmed our findings in other organisms. Taylor & Francis 2018-10-04 /pmc/articles/PMC6276844/ /pubmed/30525099 http://dx.doi.org/10.1080/23723556.2018.1526006 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Bas, Levent
Papinski, Daniel
Kraft, Claudine
Ykt6 mediates autophagosome-vacuole fusion
title Ykt6 mediates autophagosome-vacuole fusion
title_full Ykt6 mediates autophagosome-vacuole fusion
title_fullStr Ykt6 mediates autophagosome-vacuole fusion
title_full_unstemmed Ykt6 mediates autophagosome-vacuole fusion
title_short Ykt6 mediates autophagosome-vacuole fusion
title_sort ykt6 mediates autophagosome-vacuole fusion
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276844/
https://www.ncbi.nlm.nih.gov/pubmed/30525099
http://dx.doi.org/10.1080/23723556.2018.1526006
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