Timed degradation of Mcl-1 controls mitotic cell death

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that...

Descripción completa

Detalles Bibliográficos
Autores principales: Clarke, Paul R., Allan, Lindsey A., Skowyra, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276845/
https://www.ncbi.nlm.nih.gov/pubmed/30525093
http://dx.doi.org/10.1080/23723556.2018.1516450
Descripción
Sumario:Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.

Ejemplares similares