Timed degradation of Mcl-1 controls mitotic cell death

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that...

Descripción completa

Detalles Bibliográficos
Autores principales: Clarke, Paul R., Allan, Lindsey A., Skowyra, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276845/
https://www.ncbi.nlm.nih.gov/pubmed/30525093
http://dx.doi.org/10.1080/23723556.2018.1516450
_version_ 1783378078973558784
author Clarke, Paul R.
Allan, Lindsey A.
Skowyra, Agnieszka
author_facet Clarke, Paul R.
Allan, Lindsey A.
Skowyra, Agnieszka
author_sort Clarke, Paul R.
collection PubMed
description Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis.
format Online
Article
Text
id pubmed-6276845
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-62768452019-10-11 Timed degradation of Mcl-1 controls mitotic cell death Clarke, Paul R. Allan, Lindsey A. Skowyra, Agnieszka Mol Cell Oncol Author’s Views Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or cyclosome (APC/C) provides a timing mechanism that distinguishes prolonged mitotic arrest from normal mitosis. Taylor & Francis 2018-10-11 /pmc/articles/PMC6276845/ /pubmed/30525093 http://dx.doi.org/10.1080/23723556.2018.1516450 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Clarke, Paul R.
Allan, Lindsey A.
Skowyra, Agnieszka
Timed degradation of Mcl-1 controls mitotic cell death
title Timed degradation of Mcl-1 controls mitotic cell death
title_full Timed degradation of Mcl-1 controls mitotic cell death
title_fullStr Timed degradation of Mcl-1 controls mitotic cell death
title_full_unstemmed Timed degradation of Mcl-1 controls mitotic cell death
title_short Timed degradation of Mcl-1 controls mitotic cell death
title_sort timed degradation of mcl-1 controls mitotic cell death
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276845/
https://www.ncbi.nlm.nih.gov/pubmed/30525093
http://dx.doi.org/10.1080/23723556.2018.1516450
work_keys_str_mv AT clarkepaulr timeddegradationofmcl1controlsmitoticcelldeath
AT allanlindseya timeddegradationofmcl1controlsmitoticcelldeath
AT skowyraagnieszka timeddegradationofmcl1controlsmitoticcelldeath

Ejemplares similares