Wobble uridine tRNA modification: a new vulnerability of refractory melanoma

The enzymes catalysing the modification of the wobble uridine (U(34)) of tRNAs (U(34)-enzymes) play an important role in tumor development. We have recently demonstrated that the U(34)-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mR...

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Detalles Bibliográficos
Autores principales: Rapino, Francesca, Close, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276846/
https://www.ncbi.nlm.nih.gov/pubmed/30525092
http://dx.doi.org/10.1080/23723556.2018.1513725
Descripción
Sumario:The enzymes catalysing the modification of the wobble uridine (U(34)) of tRNAs (U(34)-enzymes) play an important role in tumor development. We have recently demonstrated that the U(34)-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U(34)-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U(34)-enzymes represents a new therapeutic opportunity for melanoma patients.

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