Wobble uridine tRNA modification: a new vulnerability of refractory melanoma

The enzymes catalysing the modification of the wobble uridine (U(34)) of tRNAs (U(34)-enzymes) play an important role in tumor development. We have recently demonstrated that the U(34)-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mR...

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Detalles Bibliográficos
Autores principales: Rapino, Francesca, Close, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276846/
https://www.ncbi.nlm.nih.gov/pubmed/30525092
http://dx.doi.org/10.1080/23723556.2018.1513725
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author Rapino, Francesca
Close, Pierre
author_facet Rapino, Francesca
Close, Pierre
author_sort Rapino, Francesca
collection PubMed
description The enzymes catalysing the modification of the wobble uridine (U(34)) of tRNAs (U(34)-enzymes) play an important role in tumor development. We have recently demonstrated that the U(34)-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U(34)-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U(34)-enzymes represents a new therapeutic opportunity for melanoma patients.
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spelling pubmed-62768462019-09-25 Wobble uridine tRNA modification: a new vulnerability of refractory melanoma Rapino, Francesca Close, Pierre Mol Cell Oncol Commentary The enzymes catalysing the modification of the wobble uridine (U(34)) of tRNAs (U(34)-enzymes) play an important role in tumor development. We have recently demonstrated that the U(34)-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U(34)-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U(34)-enzymes represents a new therapeutic opportunity for melanoma patients. Taylor & Francis 2018-09-25 /pmc/articles/PMC6276846/ /pubmed/30525092 http://dx.doi.org/10.1080/23723556.2018.1513725 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Rapino, Francesca
Close, Pierre
Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title_full Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title_fullStr Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title_full_unstemmed Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title_short Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
title_sort wobble uridine trna modification: a new vulnerability of refractory melanoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276846/
https://www.ncbi.nlm.nih.gov/pubmed/30525092
http://dx.doi.org/10.1080/23723556.2018.1513725
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