On your marks, get SET(D1A): the race to protect stalled replication forks

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA compleme...

Descripción completa

Detalles Bibliográficos
Autores principales: Begum, Shabana, Goula, Amalia, Bayley, Rachel, Higgs, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276854/
https://www.ncbi.nlm.nih.gov/pubmed/30525090
http://dx.doi.org/10.1080/23723556.2018.1511209
Descripción
Sumario:We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.

Ejemplares similares