On your marks, get SET(D1A): the race to protect stalled replication forks

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA compleme...

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Detalles Bibliográficos
Autores principales: Begum, Shabana, Goula, Amalia, Bayley, Rachel, Higgs, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276854/
https://www.ncbi.nlm.nih.gov/pubmed/30525090
http://dx.doi.org/10.1080/23723556.2018.1511209
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author Begum, Shabana
Goula, Amalia
Bayley, Rachel
Higgs, Martin R.
author_facet Begum, Shabana
Goula, Amalia
Bayley, Rachel
Higgs, Martin R.
author_sort Begum, Shabana
collection PubMed
description We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.
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spelling pubmed-62768542019-10-11 On your marks, get SET(D1A): the race to protect stalled replication forks Begum, Shabana Goula, Amalia Bayley, Rachel Higgs, Martin R. Mol Cell Oncol Author’s Views We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity. Taylor & Francis 2018-10-11 /pmc/articles/PMC6276854/ /pubmed/30525090 http://dx.doi.org/10.1080/23723556.2018.1511209 Text en © 2018 The Author(s). Published by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Begum, Shabana
Goula, Amalia
Bayley, Rachel
Higgs, Martin R.
On your marks, get SET(D1A): the race to protect stalled replication forks
title On your marks, get SET(D1A): the race to protect stalled replication forks
title_full On your marks, get SET(D1A): the race to protect stalled replication forks
title_fullStr On your marks, get SET(D1A): the race to protect stalled replication forks
title_full_unstemmed On your marks, get SET(D1A): the race to protect stalled replication forks
title_short On your marks, get SET(D1A): the race to protect stalled replication forks
title_sort on your marks, get set(d1a): the race to protect stalled replication forks
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276854/
https://www.ncbi.nlm.nih.gov/pubmed/30525090
http://dx.doi.org/10.1080/23723556.2018.1511209
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