Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance

Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT...

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Autores principales: Pietras, Zbigniew, Wojcik, Magdalena A., Borowski, Lukasz S., Szewczyk, Maciej, Kulinski, Tomasz M., Cysewski, Dominik, Stepien, Piotr P., Dziembowski, Andrzej, Szczesny, Roman J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276855/
https://www.ncbi.nlm.nih.gov/pubmed/30525095
http://dx.doi.org/10.1080/23723556.2018.1516452
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author Pietras, Zbigniew
Wojcik, Magdalena A.
Borowski, Lukasz S.
Szewczyk, Maciej
Kulinski, Tomasz M.
Cysewski, Dominik
Stepien, Piotr P.
Dziembowski, Andrzej
Szczesny, Roman J.
author_facet Pietras, Zbigniew
Wojcik, Magdalena A.
Borowski, Lukasz S.
Szewczyk, Maciej
Kulinski, Tomasz M.
Cysewski, Dominik
Stepien, Piotr P.
Dziembowski, Andrzej
Szczesny, Roman J.
author_sort Pietras, Zbigniew
collection PubMed
description Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT1 (also known as PNPase), together with G4-melting protein GRSF1, is a key player in restricting antisense mtRNAs.
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spelling pubmed-62768552019-09-20 Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance Pietras, Zbigniew Wojcik, Magdalena A. Borowski, Lukasz S. Szewczyk, Maciej Kulinski, Tomasz M. Cysewski, Dominik Stepien, Piotr P. Dziembowski, Andrzej Szczesny, Roman J. Mol Cell Oncol Author’s Views Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT1 (also known as PNPase), together with G4-melting protein GRSF1, is a key player in restricting antisense mtRNAs. Taylor & Francis 2018-09-20 /pmc/articles/PMC6276855/ /pubmed/30525095 http://dx.doi.org/10.1080/23723556.2018.1516452 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Pietras, Zbigniew
Wojcik, Magdalena A.
Borowski, Lukasz S.
Szewczyk, Maciej
Kulinski, Tomasz M.
Cysewski, Dominik
Stepien, Piotr P.
Dziembowski, Andrzej
Szczesny, Roman J.
Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title_full Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title_fullStr Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title_full_unstemmed Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title_short Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
title_sort controlling the mitochondrial antisense – role of the suv3-pnpase complex and its co-factor grsf1 in mitochondrial rna surveillance
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276855/
https://www.ncbi.nlm.nih.gov/pubmed/30525095
http://dx.doi.org/10.1080/23723556.2018.1516452
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