Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation

BACKGROUND: Human loss-of-function variants of ANK2 (ankyrin-B) are linked to arrhythmias and sudden cardiac death. However, their in vivo effects and specific arrhythmogenic pathways have not been fully elucidated. METHODS: We identified new ANK2 variants in 25 unrelated Han Chinese probands with v...

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Detalles Bibliográficos
Autores principales: Zhu, Wengen, Wang, Cen, Hu, Jinzhu, Wan, Rong, Yu, Jianhua, Xie, Jinyan, Ma, Jianyong, Guo, Linjuan, Ge, Jin, Qiu, Yumin, Chen, Leifeng, Liu, Hualong, Yan, Xia, Liu, Xiuxia, Ye, Jin, He, Wenfeng, Shen, Yang, Wang, Chao, Mohler, Peter J., Hong, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276866/
https://www.ncbi.nlm.nih.gov/pubmed/30571258
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034541

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