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Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking

The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT...

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Autores principales: Faraji, Jamshid, Karimi, Mitra, Soltanpour, Nabiollah, Moharrerie, Alireza, Rouhzadeh, Zahra, lotfi, Hamid, Hosseini, S Abedin, Jafari, S Yaghoob, Roudaki, Shabnam, Moeeini, Reza, Metz, Gerlinde AS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277206/
https://www.ncbi.nlm.nih.gov/pubmed/30422111
http://dx.doi.org/10.7554/eLife.40262
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author Faraji, Jamshid
Karimi, Mitra
Soltanpour, Nabiollah
Moharrerie, Alireza
Rouhzadeh, Zahra
lotfi, Hamid
Hosseini, S Abedin
Jafari, S Yaghoob
Roudaki, Shabnam
Moeeini, Reza
Metz, Gerlinde AS
author_facet Faraji, Jamshid
Karimi, Mitra
Soltanpour, Nabiollah
Moharrerie, Alireza
Rouhzadeh, Zahra
lotfi, Hamid
Hosseini, S Abedin
Jafari, S Yaghoob
Roudaki, Shabnam
Moeeini, Reza
Metz, Gerlinde AS
author_sort Faraji, Jamshid
collection PubMed
description The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations.
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spelling pubmed-62772062018-12-05 Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking Faraji, Jamshid Karimi, Mitra Soltanpour, Nabiollah Moharrerie, Alireza Rouhzadeh, Zahra lotfi, Hamid Hosseini, S Abedin Jafari, S Yaghoob Roudaki, Shabnam Moeeini, Reza Metz, Gerlinde AS eLife Neuroscience The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations. eLife Sciences Publications, Ltd 2018-11-13 /pmc/articles/PMC6277206/ /pubmed/30422111 http://dx.doi.org/10.7554/eLife.40262 Text en © 2018, Faraji et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Faraji, Jamshid
Karimi, Mitra
Soltanpour, Nabiollah
Moharrerie, Alireza
Rouhzadeh, Zahra
lotfi, Hamid
Hosseini, S Abedin
Jafari, S Yaghoob
Roudaki, Shabnam
Moeeini, Reza
Metz, Gerlinde AS
Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title_full Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title_fullStr Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title_full_unstemmed Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title_short Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
title_sort oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277206/
https://www.ncbi.nlm.nih.gov/pubmed/30422111
http://dx.doi.org/10.7554/eLife.40262
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