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Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277206/ https://www.ncbi.nlm.nih.gov/pubmed/30422111 http://dx.doi.org/10.7554/eLife.40262 |
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author | Faraji, Jamshid Karimi, Mitra Soltanpour, Nabiollah Moharrerie, Alireza Rouhzadeh, Zahra lotfi, Hamid Hosseini, S Abedin Jafari, S Yaghoob Roudaki, Shabnam Moeeini, Reza Metz, Gerlinde AS |
author_facet | Faraji, Jamshid Karimi, Mitra Soltanpour, Nabiollah Moharrerie, Alireza Rouhzadeh, Zahra lotfi, Hamid Hosseini, S Abedin Jafari, S Yaghoob Roudaki, Shabnam Moeeini, Reza Metz, Gerlinde AS |
author_sort | Faraji, Jamshid |
collection | PubMed |
description | The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations. |
format | Online Article Text |
id | pubmed-6277206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62772062018-12-05 Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking Faraji, Jamshid Karimi, Mitra Soltanpour, Nabiollah Moharrerie, Alireza Rouhzadeh, Zahra lotfi, Hamid Hosseini, S Abedin Jafari, S Yaghoob Roudaki, Shabnam Moeeini, Reza Metz, Gerlinde AS eLife Neuroscience The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations. eLife Sciences Publications, Ltd 2018-11-13 /pmc/articles/PMC6277206/ /pubmed/30422111 http://dx.doi.org/10.7554/eLife.40262 Text en © 2018, Faraji et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Faraji, Jamshid Karimi, Mitra Soltanpour, Nabiollah Moharrerie, Alireza Rouhzadeh, Zahra lotfi, Hamid Hosseini, S Abedin Jafari, S Yaghoob Roudaki, Shabnam Moeeini, Reza Metz, Gerlinde AS Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title | Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title_full | Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title_fullStr | Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title_full_unstemmed | Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title_short | Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
title_sort | oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277206/ https://www.ncbi.nlm.nih.gov/pubmed/30422111 http://dx.doi.org/10.7554/eLife.40262 |
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