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KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production

KIAA1549-BRAF is the most frequently identified genetic mutation in sporadic pilocytic astrocytoma (PA), creating a fusion BRAF (f-BRAF) protein with increased BRAF activity. Fusion-BRAF-expressing neural stem cells (NSCs) exhibit increased cell growth and can generate glioma-like lesions following...

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Detalles Bibliográficos
Autores principales:	Chen, Ran, Keoni, Chanel, Waker, Christopher A., Lober, Robert M., Gutmann, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2018
Materias:	Short communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277251/ https://www.ncbi.nlm.nih.gov/pubmed/30504064 http://dx.doi.org/10.1016/j.neo.2018.11.007

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