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Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
OBJECTIVE: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). PATIENTS AND METHODS: A retrospective, cohort study was conducted using our institution’s data fr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277264/ https://www.ncbi.nlm.nih.gov/pubmed/30534436 http://dx.doi.org/10.1016/j.aju.2018.06.004 |
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author | Singh, Onkar Nirmal, Thampi John Mukha, Rajiv Paul Mahasampath, Gowri Chandrasingh, J. Devasia, Antony Kumar, Santosh Kekre, Nitin Sudhakar |
author_facet | Singh, Onkar Nirmal, Thampi John Mukha, Rajiv Paul Mahasampath, Gowri Chandrasingh, J. Devasia, Antony Kumar, Santosh Kekre, Nitin Sudhakar |
author_sort | Singh, Onkar |
collection | PubMed |
description | OBJECTIVE: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). PATIENTS AND METHODS: A retrospective, cohort study was conducted using our institution’s data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. In all, 211 patients underwent RC for UC during the study period. The patients were divided into two groups: Group-I (n = 17) with PUM and Group-II (n = 194) with negative ureteric margins. Univariate and multivariate analyses were performed to determine the predictors of PUM. RESULTS: On univariate analysis, multifocality, tumours involving the ureteric orifice, trigonal tumours, presence of carcinoma in situ (CIS), and lymphovascular invasion at TURBT, were significantly more common in Group-I. On multivariate analysis, tumour involvement in the ureteric orifice(s) and presence of associated CIS significantly predicted PUM. CONCLUSIONS: Primary tumour-related factors on initial TURBT that predicted PUM (at RC) were involvement of the ureteric orifice(s) and presence of associated CIS. These results may help to select patients who can be selectively offered intraoperative frozen section analysis. |
format | Online Article Text |
id | pubmed-6277264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62772642018-12-10 Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? Singh, Onkar Nirmal, Thampi John Mukha, Rajiv Paul Mahasampath, Gowri Chandrasingh, J. Devasia, Antony Kumar, Santosh Kekre, Nitin Sudhakar Arab J Urol Oncology/Reconstruction OBJECTIVE: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). PATIENTS AND METHODS: A retrospective, cohort study was conducted using our institution’s data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. In all, 211 patients underwent RC for UC during the study period. The patients were divided into two groups: Group-I (n = 17) with PUM and Group-II (n = 194) with negative ureteric margins. Univariate and multivariate analyses were performed to determine the predictors of PUM. RESULTS: On univariate analysis, multifocality, tumours involving the ureteric orifice, trigonal tumours, presence of carcinoma in situ (CIS), and lymphovascular invasion at TURBT, were significantly more common in Group-I. On multivariate analysis, tumour involvement in the ureteric orifice(s) and presence of associated CIS significantly predicted PUM. CONCLUSIONS: Primary tumour-related factors on initial TURBT that predicted PUM (at RC) were involvement of the ureteric orifice(s) and presence of associated CIS. These results may help to select patients who can be selectively offered intraoperative frozen section analysis. Elsevier 2018-07-14 /pmc/articles/PMC6277264/ /pubmed/30534436 http://dx.doi.org/10.1016/j.aju.2018.06.004 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of Arab Association of Urology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology/Reconstruction Singh, Onkar Nirmal, Thampi John Mukha, Rajiv Paul Mahasampath, Gowri Chandrasingh, J. Devasia, Antony Kumar, Santosh Kekre, Nitin Sudhakar Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title | Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title_full | Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title_fullStr | Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title_full_unstemmed | Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title_short | Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour? |
title_sort | positive ureteric margins at radical cystectomy: can it be predicted at initial transurethral resection of bladder tumour? |
topic | Oncology/Reconstruction |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277264/ https://www.ncbi.nlm.nih.gov/pubmed/30534436 http://dx.doi.org/10.1016/j.aju.2018.06.004 |
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