Felis catus papillomavirus type-2 E6 binds to E6AP, promotes E6AP/p53 binding and enhances p53 proteasomal degradation

E6 from high risk human papillomaviruses (HR HPVs) promotes ubiquitination and degradation of p53 tumour suppressor by mediating its binding to ubiquitin ligase E6AP in a ternary complex, contributing to cell transformation in cervical cancer. We have previously shown that Felis catus papillomavirus...

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Detalles Bibliográficos
Autores principales: Altamura, Gennaro, Power, Karen, Martano, Manuela, degli Uberti, Barbara, Galiero, Giorgio, De Luca, Giovanna, Maiolino, Paola, Borzacchiello, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277439/
https://www.ncbi.nlm.nih.gov/pubmed/30510267
http://dx.doi.org/10.1038/s41598-018-35723-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277439/
https://www.ncbi.nlm.nih.gov/pubmed/30510267
http://dx.doi.org/10.1038/s41598-018-35723-7

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