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Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers

Mycolic acid (MA), a major lipid component of Mycobacterium tuberculosis (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals. These MA-specific CD1b-restricted T cells are cytotoxic, produce Th1 cytokines, and fo...

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Detalles Bibliográficos
Autores principales:	Shang, Shaobin, Kats, Dina, Cao, Liang, Morgun, Eva, Velluto, Diana, He, Ying, Xu, Qichen, Wang, Chyung-Ru, Scott, Evan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277542/ https://www.ncbi.nlm.nih.gov/pubmed/30538700 http://dx.doi.org/10.3389/fimmu.2018.02709

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