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Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus)
OBJECTIVE: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. METHODS: Ninety 8-week-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Reproductive Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277668/ https://www.ncbi.nlm.nih.gov/pubmed/30538946 http://dx.doi.org/10.5653/cerm.2018.45.4.163 |
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author | Ahmad, Bashir Shrivastava, Vinoy K. Saleh, Ramadan Henkel, Ralf Agarwal, Ashok |
author_facet | Ahmad, Bashir Shrivastava, Vinoy K. Saleh, Ramadan Henkel, Ralf Agarwal, Ashok |
author_sort | Ahmad, Bashir |
collection | PubMed |
description | OBJECTIVE: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. METHODS: Ninety 8-week-old female mice were randomly allocated into three treatment groups. The first group received an intraperitoneal injection of ZEA (2.5 mg/kg) on alternate days. The second group received ZEA (2.5 mg/kg) on alternate days plus oral saffron daily (50 mg/kg). The third group was treated with a vehicle of 1% dimethyl sulfoxide (DMSO) on alternate days, as a control. Ten mice were euthanized from each group at 30, 60, and 90 days of treatment. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E(2)), and progesterone (P) were assessed. The uterus and ovaries were examined for changes in size or morphology. RESULTS: Serum levels of LH, FSH, E(2), and P in the female mice treated with ZEA plus saffron were significantly higher than in those treated with ZEA alone, and were not significantly different from those treated with 1% DMSO. The female mice treated with ZEA alone showed a reduction in size of the uterus and abnormal architecture of the ovaries. CONCLUSION: The administration of saffron to female mice resulted in a significant reduction in ZEA-induced alterations in reproductive hormone levels, the size of the uterus, and the morphology of the ovaries. |
format | Online Article Text |
id | pubmed-6277668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-62776682018-12-11 Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) Ahmad, Bashir Shrivastava, Vinoy K. Saleh, Ramadan Henkel, Ralf Agarwal, Ashok Clin Exp Reprod Med Original Article OBJECTIVE: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. METHODS: Ninety 8-week-old female mice were randomly allocated into three treatment groups. The first group received an intraperitoneal injection of ZEA (2.5 mg/kg) on alternate days. The second group received ZEA (2.5 mg/kg) on alternate days plus oral saffron daily (50 mg/kg). The third group was treated with a vehicle of 1% dimethyl sulfoxide (DMSO) on alternate days, as a control. Ten mice were euthanized from each group at 30, 60, and 90 days of treatment. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E(2)), and progesterone (P) were assessed. The uterus and ovaries were examined for changes in size or morphology. RESULTS: Serum levels of LH, FSH, E(2), and P in the female mice treated with ZEA plus saffron were significantly higher than in those treated with ZEA alone, and were not significantly different from those treated with 1% DMSO. The female mice treated with ZEA alone showed a reduction in size of the uterus and abnormal architecture of the ovaries. CONCLUSION: The administration of saffron to female mice resulted in a significant reduction in ZEA-induced alterations in reproductive hormone levels, the size of the uterus, and the morphology of the ovaries. The Korean Society for Reproductive Medicine 2018-12 2018-11-30 /pmc/articles/PMC6277668/ /pubmed/30538946 http://dx.doi.org/10.5653/cerm.2018.45.4.163 Text en Copyright © 2018. The Korean Society for Reproductive Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ahmad, Bashir Shrivastava, Vinoy K. Saleh, Ramadan Henkel, Ralf Agarwal, Ashok Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title | Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title_full | Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title_fullStr | Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title_full_unstemmed | Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title_short | Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus) |
title_sort | protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (mus musculus) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277668/ https://www.ncbi.nlm.nih.gov/pubmed/30538946 http://dx.doi.org/10.5653/cerm.2018.45.4.163 |
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