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Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito
Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese trad...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277701/ https://www.ncbi.nlm.nih.gov/pubmed/30538991 http://dx.doi.org/10.3389/fnut.2018.00112 |
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author | Hosogi, Shigekuni Ohsawa, Masahiro Kato, Ikuo Kuwahara, Atsukazu Inui, Toshio Inui, Akio Marunaka, Yoshinori |
author_facet | Hosogi, Shigekuni Ohsawa, Masahiro Kato, Ikuo Kuwahara, Atsukazu Inui, Toshio Inui, Akio Marunaka, Yoshinori |
author_sort | Hosogi, Shigekuni |
collection | PubMed |
description | Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese traditional herbal medicines for improving various types of metabolic disorders. However, the effect of NYT on diabetes mellitus has not yet been investigated. In the present study, we tried to clarify the action of NYT on the serum glucose level in streptozotocin (STZ)-induced diabetic mice. We found that intake of NYT decreased the serum glucose level and increased insulin sensitivity in STZ-induced diabetic mice. NYT treatment also improved acidification of the interstitial fluid around skeletal muscles found in STZ-induced diabetic mice, while the interstitial fluid acidification has been reported to cause insulin resistance. Furthermore, in the proximal colon of STZ-induced diabetic mice, NYT treatment showed a tendency to increase the expression of sodium-coupled monocarboxylate transporter 1 (SMCT1), which has ability to absorb weak organic acids (pH buffer molecules) resulting in improvement of the interstitial fluid acidification. Based on these observations, the present study suggests that NYT is a useful formula to improve hyperglycemia and insulin resistance via elevation of interstitial fluid pH in diabetes mellitus, which might be caused by increased absorption of pH buffer molecules (SMCT1 substrates, weak organic acids) mediated through possibly elevated SMCT1 expression in the proximal colon. |
format | Online Article Text |
id | pubmed-6277701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62777012018-12-11 Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito Hosogi, Shigekuni Ohsawa, Masahiro Kato, Ikuo Kuwahara, Atsukazu Inui, Toshio Inui, Akio Marunaka, Yoshinori Front Nutr Nutrition Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese traditional herbal medicines for improving various types of metabolic disorders. However, the effect of NYT on diabetes mellitus has not yet been investigated. In the present study, we tried to clarify the action of NYT on the serum glucose level in streptozotocin (STZ)-induced diabetic mice. We found that intake of NYT decreased the serum glucose level and increased insulin sensitivity in STZ-induced diabetic mice. NYT treatment also improved acidification of the interstitial fluid around skeletal muscles found in STZ-induced diabetic mice, while the interstitial fluid acidification has been reported to cause insulin resistance. Furthermore, in the proximal colon of STZ-induced diabetic mice, NYT treatment showed a tendency to increase the expression of sodium-coupled monocarboxylate transporter 1 (SMCT1), which has ability to absorb weak organic acids (pH buffer molecules) resulting in improvement of the interstitial fluid acidification. Based on these observations, the present study suggests that NYT is a useful formula to improve hyperglycemia and insulin resistance via elevation of interstitial fluid pH in diabetes mellitus, which might be caused by increased absorption of pH buffer molecules (SMCT1 substrates, weak organic acids) mediated through possibly elevated SMCT1 expression in the proximal colon. Frontiers Media S.A. 2018-11-27 /pmc/articles/PMC6277701/ /pubmed/30538991 http://dx.doi.org/10.3389/fnut.2018.00112 Text en Copyright © 2018 Hosogi, Ohsawa, Kato, Kuwahara, Inui, Inui and Marunaka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Hosogi, Shigekuni Ohsawa, Masahiro Kato, Ikuo Kuwahara, Atsukazu Inui, Toshio Inui, Akio Marunaka, Yoshinori Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title | Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title_full | Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title_fullStr | Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title_full_unstemmed | Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title_short | Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito |
title_sort | improvement of diabetes mellitus symptoms by intake of ninjin'yoeito |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277701/ https://www.ncbi.nlm.nih.gov/pubmed/30538991 http://dx.doi.org/10.3389/fnut.2018.00112 |
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