Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes

The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fung...

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Detalles Bibliográficos
Autores principales: Pöthig, Alexander, Ahmed, Sara, Winther-Larsen, Hanne Cecilie, Guan, Shengyang, Altmann, Philipp J., Kudermann, Jürgen, Santos Andresen, Adriana Magalhães, Gjøen, Tor, Høgmoen Åstrand, Ove Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277803/
https://www.ncbi.nlm.nih.gov/pubmed/30542649
http://dx.doi.org/10.3389/fchem.2018.00584
Descripción
Sumario:The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fungus (Candida albicans), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.

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