Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes

The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fung...

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Autores principales: Pöthig, Alexander, Ahmed, Sara, Winther-Larsen, Hanne Cecilie, Guan, Shengyang, Altmann, Philipp J., Kudermann, Jürgen, Santos Andresen, Adriana Magalhães, Gjøen, Tor, Høgmoen Åstrand, Ove Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277803/
https://www.ncbi.nlm.nih.gov/pubmed/30542649
http://dx.doi.org/10.3389/fchem.2018.00584
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author Pöthig, Alexander
Ahmed, Sara
Winther-Larsen, Hanne Cecilie
Guan, Shengyang
Altmann, Philipp J.
Kudermann, Jürgen
Santos Andresen, Adriana Magalhães
Gjøen, Tor
Høgmoen Åstrand, Ove Alexander
author_facet Pöthig, Alexander
Ahmed, Sara
Winther-Larsen, Hanne Cecilie
Guan, Shengyang
Altmann, Philipp J.
Kudermann, Jürgen
Santos Andresen, Adriana Magalhães
Gjøen, Tor
Høgmoen Åstrand, Ove Alexander
author_sort Pöthig, Alexander
collection PubMed
description The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fungus (Candida albicans), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.
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spelling pubmed-62778032018-12-12 Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes Pöthig, Alexander Ahmed, Sara Winther-Larsen, Hanne Cecilie Guan, Shengyang Altmann, Philipp J. Kudermann, Jürgen Santos Andresen, Adriana Magalhães Gjøen, Tor Høgmoen Åstrand, Ove Alexander Front Chem Chemistry The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fungus (Candida albicans), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells. Frontiers Media S.A. 2018-11-27 /pmc/articles/PMC6277803/ /pubmed/30542649 http://dx.doi.org/10.3389/fchem.2018.00584 Text en Copyright © 2018 Pöthig, Ahmed, Winther-Larsen, Guan, Altmann, Kudermann, Santos Andresen, Gjøen and Høgmoen Åstrand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Pöthig, Alexander
Ahmed, Sara
Winther-Larsen, Hanne Cecilie
Guan, Shengyang
Altmann, Philipp J.
Kudermann, Jürgen
Santos Andresen, Adriana Magalhães
Gjøen, Tor
Høgmoen Åstrand, Ove Alexander
Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title_full Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title_fullStr Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title_full_unstemmed Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title_short Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes
title_sort antimicrobial activity and cytotoxicity of ag(i) and au(i) pillarplexes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277803/
https://www.ncbi.nlm.nih.gov/pubmed/30542649
http://dx.doi.org/10.3389/fchem.2018.00584
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