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Insulin Resistance in Alzheimer's Disease

The epidemiological connection between diabetes, obesity, and dementia represents an important public health challenge but also an opportunity to further understand these conditions. The key intersection among the three diseases is insulin resistance, which has been classically described to occur in...

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Autores principales: Ferreira, Laís S. S., Fernandes, Caroline S., Vieira, Marcelo N. N., De Felice, Fernanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277874/
https://www.ncbi.nlm.nih.gov/pubmed/30542257
http://dx.doi.org/10.3389/fnins.2018.00830
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author Ferreira, Laís S. S.
Fernandes, Caroline S.
Vieira, Marcelo N. N.
De Felice, Fernanda G.
author_facet Ferreira, Laís S. S.
Fernandes, Caroline S.
Vieira, Marcelo N. N.
De Felice, Fernanda G.
author_sort Ferreira, Laís S. S.
collection PubMed
description The epidemiological connection between diabetes, obesity, and dementia represents an important public health challenge but also an opportunity to further understand these conditions. The key intersection among the three diseases is insulin resistance, which has been classically described to occur in peripheral tissues in diabetes and obesity and has recently been shown to develop in Alzheimer's disease (AD) brains. Here we review encouraging preclinical and clinical data indicating the potential of targeting impaired insulin signaling with antidiabetic drugs to treat dementia. We further discuss biological mechanisms through which peripheral metabolic dysregulation may lead to brain malfunction, providing possible explanations for the connection between diabetes, obesity, and AD. Finally, we briefly discuss how lifelong allostatic load may interact with aging to increase the risk of dementia in late life.
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spelling pubmed-62778742018-12-12 Insulin Resistance in Alzheimer's Disease Ferreira, Laís S. S. Fernandes, Caroline S. Vieira, Marcelo N. N. De Felice, Fernanda G. Front Neurosci Neuroscience The epidemiological connection between diabetes, obesity, and dementia represents an important public health challenge but also an opportunity to further understand these conditions. The key intersection among the three diseases is insulin resistance, which has been classically described to occur in peripheral tissues in diabetes and obesity and has recently been shown to develop in Alzheimer's disease (AD) brains. Here we review encouraging preclinical and clinical data indicating the potential of targeting impaired insulin signaling with antidiabetic drugs to treat dementia. We further discuss biological mechanisms through which peripheral metabolic dysregulation may lead to brain malfunction, providing possible explanations for the connection between diabetes, obesity, and AD. Finally, we briefly discuss how lifelong allostatic load may interact with aging to increase the risk of dementia in late life. Frontiers Media S.A. 2018-11-13 /pmc/articles/PMC6277874/ /pubmed/30542257 http://dx.doi.org/10.3389/fnins.2018.00830 Text en Copyright © 2018 Ferreira, Fernandes, Vieira and De Felice. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ferreira, Laís S. S.
Fernandes, Caroline S.
Vieira, Marcelo N. N.
De Felice, Fernanda G.
Insulin Resistance in Alzheimer's Disease
title Insulin Resistance in Alzheimer's Disease
title_full Insulin Resistance in Alzheimer's Disease
title_fullStr Insulin Resistance in Alzheimer's Disease
title_full_unstemmed Insulin Resistance in Alzheimer's Disease
title_short Insulin Resistance in Alzheimer's Disease
title_sort insulin resistance in alzheimer's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277874/
https://www.ncbi.nlm.nih.gov/pubmed/30542257
http://dx.doi.org/10.3389/fnins.2018.00830
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