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Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. Much progress has been made in understanding the mechanism of activation of human CAR by drugs and xenobiotics. Howe...

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Detalles Bibliográficos
Autores principales:	McMahon, Michael, Ding, Shaohong, Jimenez, Lourdes Acosta, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan, Henderson, Colin J., Wolf, C. Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277922/ https://www.ncbi.nlm.nih.gov/pubmed/30361333 http://dx.doi.org/10.1124/mol.118.113555

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