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Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells

BACKGROUND: TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell-invasive phenotype. We found that AMAP1 levels...

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Detalles Bibliográficos
Autores principales:	Handa, Haruka, Hashimoto, Ari, Hashimoto, Shigeru, Sugino, Hirokazu, Oikawa, Tsukasa, Sabe, Hisataka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278066/ https://www.ncbi.nlm.nih.gov/pubmed/30509302 http://dx.doi.org/10.1186/s12964-018-0302-6

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