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Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis

BACKGROUND: Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk. METHODS: Literature retrieve was conducted in Pu...

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Detalles Bibliográficos
Autores principales: Liu, Zhengling, Wang, Zengyan, Hao, Changhong, Tian, Yonghui, Fu, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278103/
https://www.ncbi.nlm.nih.gov/pubmed/30509295
http://dx.doi.org/10.1186/s12958-018-0439-6
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author Liu, Zhengling
Wang, Zengyan
Hao, Changhong
Tian, Yonghui
Fu, Jingjing
author_facet Liu, Zhengling
Wang, Zengyan
Hao, Changhong
Tian, Yonghui
Fu, Jingjing
author_sort Liu, Zhengling
collection PubMed
description BACKGROUND: Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk. METHODS: Literature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: Eighteen studies were enrolled for analyses. Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk (recessive model: p = 0.02, OR = 0.77, 95%CI 0.62–0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06–1.26). Further subgroup analyses according to ethnicity of participants revealed that rs1501299 and rs2241766 polymorphisms were both significantly correlated with PCOS risk in Caucasians. In addition, rs1501299 polymorphism was also significantly correlated with PCOS risk in East Asians. CONCLUSIONS: Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities.
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spelling pubmed-62781032018-12-10 Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis Liu, Zhengling Wang, Zengyan Hao, Changhong Tian, Yonghui Fu, Jingjing Reprod Biol Endocrinol Research BACKGROUND: Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk. METHODS: Literature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: Eighteen studies were enrolled for analyses. Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk (recessive model: p = 0.02, OR = 0.77, 95%CI 0.62–0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06–1.26). Further subgroup analyses according to ethnicity of participants revealed that rs1501299 and rs2241766 polymorphisms were both significantly correlated with PCOS risk in Caucasians. In addition, rs1501299 polymorphism was also significantly correlated with PCOS risk in East Asians. CONCLUSIONS: Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities. BioMed Central 2018-12-03 /pmc/articles/PMC6278103/ /pubmed/30509295 http://dx.doi.org/10.1186/s12958-018-0439-6 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Liu, Zhengling
Wang, Zengyan
Hao, Changhong
Tian, Yonghui
Fu, Jingjing
Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title_full Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title_fullStr Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title_full_unstemmed Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title_short Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis
title_sort effects of adipoq polymorphisms on pcos risk: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278103/
https://www.ncbi.nlm.nih.gov/pubmed/30509295
http://dx.doi.org/10.1186/s12958-018-0439-6
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