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Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria

Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to th...

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Detalles Bibliográficos
Autores principales: Lin, Fengming, Bao, Yan-Wen, Wu, Fu-Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278291/
https://www.ncbi.nlm.nih.gov/pubmed/30453692
http://dx.doi.org/10.3390/molecules23113016
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author Lin, Fengming
Bao, Yan-Wen
Wu, Fu-Gen
author_facet Lin, Fengming
Bao, Yan-Wen
Wu, Fu-Gen
author_sort Lin, Fengming
collection PubMed
description Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds.
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spelling pubmed-62782912018-12-13 Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria Lin, Fengming Bao, Yan-Wen Wu, Fu-Gen Molecules Review Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds. MDPI 2018-11-18 /pmc/articles/PMC6278291/ /pubmed/30453692 http://dx.doi.org/10.3390/molecules23113016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Fengming
Bao, Yan-Wen
Wu, Fu-Gen
Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title_full Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title_fullStr Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title_full_unstemmed Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title_short Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
title_sort improving the phototherapeutic efficiencies of molecular and nanoscale materials by targeting mitochondria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278291/
https://www.ncbi.nlm.nih.gov/pubmed/30453692
http://dx.doi.org/10.3390/molecules23113016
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