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Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278291/ https://www.ncbi.nlm.nih.gov/pubmed/30453692 http://dx.doi.org/10.3390/molecules23113016 |
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author | Lin, Fengming Bao, Yan-Wen Wu, Fu-Gen |
author_facet | Lin, Fengming Bao, Yan-Wen Wu, Fu-Gen |
author_sort | Lin, Fengming |
collection | PubMed |
description | Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds. |
format | Online Article Text |
id | pubmed-6278291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62782912018-12-13 Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria Lin, Fengming Bao, Yan-Wen Wu, Fu-Gen Molecules Review Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds. MDPI 2018-11-18 /pmc/articles/PMC6278291/ /pubmed/30453692 http://dx.doi.org/10.3390/molecules23113016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Fengming Bao, Yan-Wen Wu, Fu-Gen Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title_full | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title_fullStr | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title_full_unstemmed | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title_short | Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria |
title_sort | improving the phototherapeutic efficiencies of molecular and nanoscale materials by targeting mitochondria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278291/ https://www.ncbi.nlm.nih.gov/pubmed/30453692 http://dx.doi.org/10.3390/molecules23113016 |
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