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Novel Transforming Growth Factor-Beta Receptor 1 Antagonists through a Pharmacophore-Based Virtual Screening Approach

As new drugs for the treatment of malignant tumors, transforming growth factor-beta receptor 1 (TGFβR1) antagonists have attracted wide attention. Based on the crystal structure of TGFβR1-BMS22 complex, the pharmacophore model A02 with two hydrogen bond acceptors (HBAs) and four hydrophobic (HYD) pr...

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Detalles Bibliográficos
Autores principales:	Jiang, Junhao, Zhou, Hui, Jiang, Qihua, Sun, Lili, Deng, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278322/ https://www.ncbi.nlm.nih.gov/pubmed/30384428 http://dx.doi.org/10.3390/molecules23112824

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