Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

BACKGROUND: Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a protein conjugated polysaccharide vaccine. Previous studies on the human immun...

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Detalles Bibliográficos
Autores principales: Chen, Zhifeng, Cox, Kara S., Tang, Aimin, Roman, Jeanette, Fink, Malorie, Kaufhold, Robin M., Guan, Liming, Xie, Andy, Boddicker, Melissa A., Mcguinness, Debra, Xiao, Xiao, Li, Hualin, Skinner, Julie M., Verch, Thorsten, Retzlaff, Mary, Vora, Kalpit A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278343/
https://www.ncbi.nlm.nih.gov/pubmed/30509199
http://dx.doi.org/10.1186/s12879-018-3517-7

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