Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods

The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors. Generally, the primary role of orexins is to act as excitatory neurotransmitters and regulate the sleep process. Lack of orexins ma...

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Detalles Bibliográficos
Autores principales: Janockova, Jana, Dolezal, Rafael, Nepovimova, Eugenie, Kobrlova, Tereza, Benkova, Marketa, Kuca, Kamil, Konecny, Jan, Mezeiova, Eva, Melikova, Michaela, Hepnarova, Vendula, Ring, Avi, Soukup, Ondrej, Korabecny, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278354/
https://www.ncbi.nlm.nih.gov/pubmed/30423961
http://dx.doi.org/10.3390/molecules23112926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278354/
https://www.ncbi.nlm.nih.gov/pubmed/30423961
http://dx.doi.org/10.3390/molecules23112926

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