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In Silico Prediction of O(6)-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods

O(6)-methylguanine-DNA methyltransferase (MGMT), a unique DNA repair enzyme, can confer resistance to DNA anticancer alkylating agents that modify the O(6)-position of guanine. Thus, inhibition of MGMT activity in tumors has a great interest for cancer researchers because it can significantly improv...

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Detalles Bibliográficos
Autores principales:	Sun, Guohui, Fan, Tengjiao, Sun, Xiaodong, Hao, Yuxing, Cui, Xin, Zhao, Lijiao, Ren, Ting, Zhou, Yue, Zhong, Rugang, Peng, Yongzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278368/ https://www.ncbi.nlm.nih.gov/pubmed/30404161 http://dx.doi.org/10.3390/molecules23112892

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