Cargando…

Preclinical Pharmacokinetics of C118P, a Novel Prodrug of Microtubules Inhibitor and Its Metabolite C118 in Mice, Rats, and Dogs

C118P, a phosphate prodrug of C118, which is a novel microtubule protein inhibitor, is currently under Phase I clinical development in China for treating ovarian cancer and lung cancer. The preclinical pharmacokinetics of prodrug C118P and its metabolite C118 were extensively characterized in vivo i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Cang, Zhang, Xiaolan, Wang, Guangji, Peng, Ying, Zhang, Xueyuan, Wu, Hui, Yu, Boyang, Sun, Jianguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278385/ https://www.ncbi.nlm.nih.gov/pubmed/30400617 http://dx.doi.org/10.3390/molecules23112883

Ejemplares similares

Klaviertücke Op. 118
por: Brahms, Johannes, 1833-1897
Publicado: (1976)

118th SPSC Meeting
Publicado: (2015)

118th LHCC Meeting
Publicado: (2014)

Study of the polarization of antiproton in scattering at 1.18 GeV/c
por: Dobrzynski, L, et al.
Publicado: (1966)

Decreased tumorigenesis in mice with a Kras point mutation at C118
por: Huang, Lu, et al.
Publicado: (2014)

Health Tract, No. 118: Children’s Eating
Publicado: (1862)

Health Tract, No. 118: Children’s Eating
Publicado: (1865)

Studies of the structures of $^{118,120}$Cd using $^{118,120}$Ag $\beta$-decay of laser-selected isomers
por: Garrett, Paul
Publicado: (2022)

ALPHA User'Guide (Version 117/118)
por: Boucrot, J, et al.
Publicado: (1994)

A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
por: Lyu, Xiao-Dan, et al.
Publicado: (2023)

Addendum to the proposal SPSC-P-88 (77-118)
por: CERN. Geneva. SPS Experiments Committee
Publicado: (1977)

Unitary representations of reductive lie groups (AM-118)
por: Vogan, David A, Jr, et al.
Publicado: (1988)

Analysis of 118 Cases of Leprosy in the Tarntaran Asylum (Punjab)
por: Abraham, Phineas S.
Publicado: (1891)

Abstract 118: Primary hyperaldosteronism presenting as subarachnoid hemorrhage
por: Panikar, Krish, et al.
Publicado: (2022)

118. Quantitative Assessments of Finger Individuation with an Instrumented Glove
por: Conway, Brian J., et al.
Publicado: (2023)

AB118. Effect of MOTILIPERM in cisplatin administered SD rats
por: Soni, Kiran Kumar, et al.
Publicado: (2016)

Clinical characteristics, treatment, and prognosis of 118 cases of myeloid sarcoma
por: Zhao, Haiqiu, et al.
Publicado: (2022)

Status report on the experiment S118 for the chairman of the E.E.C. for the report on experimental programme at the PS
por: CERN. Geneva
Publicado: (1973)

Molecular screening for the mutation associated with canine degenerative myelopathy (SOD1:c.118G > A) in German Shepherd dogs in Brazil
por: Santos, Cássia Regina Oliveira, et al.
Publicado: (2020)

A multi-center psychometric evaluation of the Severity Indices of Personality Problems 118 (SIPP-118): Do we really need all those facets?
por: Paap, Muirne C. S., et al.
Publicado: (2020)

Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models
por: Hong, Xiaodan, et al.
Publicado: (2022)

Understanding the pharmacokinetics of prodrug and metabolite
por: Cho, Seungil, et al.
Publicado: (2018)

Genome Characterisation of Enteroviruses 117 and 118: A New Group within Human Enterovirus Species C
por: Piralla, Antonio, et al.
Publicado: (2013)

Reduced HRAS(G12V)-Driven Tumorigenesis of Cell Lines Expressing KRAS(C118S)
por: Huang, Lu, et al.
Publicado: (2015)

Successful resuscitation from accidental hypothermia of 11.8°C: where is the lower bound for human beings?
por: Mroczek, Tomasz, et al.
Publicado: (2020)

Beta-delayed $\alpha$-emission from $^{118,120}$Cs
por: Hornshøj, P, et al.
Publicado: (1975)

Decay studies of the neutron-deficient isotopes $^{114-118}Ba$
por: Janas, Z, et al.
Publicado: (1997)

Properties of the lightest known caesium isotopes, $^{114-118}$Cs
por: D'Auria, J M, et al.
Publicado: (1978)

Studies on the decay of $^{120}$Cs, $^{118}$Cs and $^{116}$Cs
por: Batsch, T, et al.
Publicado: (1976)

Runs 117', 118', 119', 122', 123', both Rings
por: Keil, Eberhard
Publicado: (1971)

1,18 Billionen Volt: Urknallmaschine stellt Weltrekord auf
Publicado: (2009)

EPH118 Healthcare Systems Sustainability and Resilience: Creating an Index
por: Besley, S, et al.
Publicado: (2022)

SAT-LB118 Euglycemic Diabetic Ketoacidosis in Type 2 Diabetes Mellitus
por: Arao, Kevin A, et al.
Publicado: (2020)

MON-118 Reducing Unnecessary Repeat HbA1c Testing in a Tertiary Academic Hospital
por: Rajeswaran, Vamana, et al.
Publicado: (2020)

Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling
por: North, Justin A., et al.
Publicado: (2011)

Search for right-handed currents in the $\beta^{\pm}$ decay of $^{118}/Sb$
por: Vereecke, B, et al.
Publicado: (2000)

Beta-delayed $\chi$ emission from $^{118}Cs$ and $^{120}Cs$
por: Hornshøj, P, et al.
Publicado: (1975)

Time series analysis of background signals, Runs 116, 117, 118
por: Hübner, K, et al.
Publicado: (1972)

Run 118, 15 GeV, 15 FA, 4 bunches
por: Gröbner, Oswald
Publicado: (1971)

The CERN 1.18 m3 Heavy Liquid Bubble Chamber
por: Actis, P, et al.
Publicado: (1965)

Cannot write session to /tmp/vufind_sessions/sess_taomri6j6f509iui0gt8s7iifl