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New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)

Helicteres velutina K. Schum (Sterculiaceae), commonly known in Brazil as ‘pitó’, is traditionally used by indigenous peoples as insecticides and repellents. The present work reports on the the phytoconstituents from aerial parts of H. velutina and evaluation of the larvicidal potential of its extra...

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Autores principales: Fernandes, Diégina A., Souza, Maria S. R., Teles, Yanna C. F., Oliveira, Louise H. G., Lima, Jéssica B., Conceição, Adilva S., Nunes, Fabíola C., Silva, Tania M. S., de Souza, Maria de Fátima Vanderlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278388/
https://www.ncbi.nlm.nih.gov/pubmed/30373225
http://dx.doi.org/10.3390/molecules23112784
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author Fernandes, Diégina A.
Souza, Maria S. R.
Teles, Yanna C. F.
Oliveira, Louise H. G.
Lima, Jéssica B.
Conceição, Adilva S.
Nunes, Fabíola C.
Silva, Tania M. S.
de Souza, Maria de Fátima Vanderlei
author_facet Fernandes, Diégina A.
Souza, Maria S. R.
Teles, Yanna C. F.
Oliveira, Louise H. G.
Lima, Jéssica B.
Conceição, Adilva S.
Nunes, Fabíola C.
Silva, Tania M. S.
de Souza, Maria de Fátima Vanderlei
author_sort Fernandes, Diégina A.
collection PubMed
description Helicteres velutina K. Schum (Sterculiaceae), commonly known in Brazil as ‘pitó’, is traditionally used by indigenous peoples as insecticides and repellents. The present work reports on the the phytoconstituents from aerial parts of H. velutina and evaluation of the larvicidal potential of its extract. The compounds were isolated using chromatographic techniques and identified by NMR, IR and LC-HRMS. This study led to the isolation of a fatty acid, one aliphatic alcohol, four chlorophyll derivatives, one steroid, triterpenes, a lignan, and flavonoids, highlighting the new compounds in the literature, 5,4′-di-hydroxy-7-methoxy-8-O-sulphate flavone (mariahine) (15a) and 5,3′-di-hydroxy-7,4′-dimethoxy-8-O-sulphate flavone (condadine) (15b). The work presented here contributes to the chemotaxonomic knowledge of the Sterculiaceae family by describing the occurrence of sulphated flavonoids in this family for the first time. The crude ethanolic extract of H. velutina featured robust larvicidal activity against Aedes aegypti larvae, showing that the extract can be useful as a domestic larvicide, just as indicated by traditional use, to combat A. aegypti, a vector insect of severe viral diseases, such as dengue and Zika.
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spelling pubmed-62783882018-12-13 New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae) Fernandes, Diégina A. Souza, Maria S. R. Teles, Yanna C. F. Oliveira, Louise H. G. Lima, Jéssica B. Conceição, Adilva S. Nunes, Fabíola C. Silva, Tania M. S. de Souza, Maria de Fátima Vanderlei Molecules Article Helicteres velutina K. Schum (Sterculiaceae), commonly known in Brazil as ‘pitó’, is traditionally used by indigenous peoples as insecticides and repellents. The present work reports on the the phytoconstituents from aerial parts of H. velutina and evaluation of the larvicidal potential of its extract. The compounds were isolated using chromatographic techniques and identified by NMR, IR and LC-HRMS. This study led to the isolation of a fatty acid, one aliphatic alcohol, four chlorophyll derivatives, one steroid, triterpenes, a lignan, and flavonoids, highlighting the new compounds in the literature, 5,4′-di-hydroxy-7-methoxy-8-O-sulphate flavone (mariahine) (15a) and 5,3′-di-hydroxy-7,4′-dimethoxy-8-O-sulphate flavone (condadine) (15b). The work presented here contributes to the chemotaxonomic knowledge of the Sterculiaceae family by describing the occurrence of sulphated flavonoids in this family for the first time. The crude ethanolic extract of H. velutina featured robust larvicidal activity against Aedes aegypti larvae, showing that the extract can be useful as a domestic larvicide, just as indicated by traditional use, to combat A. aegypti, a vector insect of severe viral diseases, such as dengue and Zika. MDPI 2018-10-27 /pmc/articles/PMC6278388/ /pubmed/30373225 http://dx.doi.org/10.3390/molecules23112784 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernandes, Diégina A.
Souza, Maria S. R.
Teles, Yanna C. F.
Oliveira, Louise H. G.
Lima, Jéssica B.
Conceição, Adilva S.
Nunes, Fabíola C.
Silva, Tania M. S.
de Souza, Maria de Fátima Vanderlei
New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title_full New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title_fullStr New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title_full_unstemmed New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title_short New Sulphated Flavonoids and Larvicidal Activity of Helicteres velutina K. Schum (Sterculiaceae)
title_sort new sulphated flavonoids and larvicidal activity of helicteres velutina k. schum (sterculiaceae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278388/
https://www.ncbi.nlm.nih.gov/pubmed/30373225
http://dx.doi.org/10.3390/molecules23112784
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