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The Radiostability of Meropenem Trihydrate in Solid State
The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No ch...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278425/ https://www.ncbi.nlm.nih.gov/pubmed/30360551 http://dx.doi.org/10.3390/molecules23112738 |
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author | Kilińska, Karolina Cielecka-Piontek, Judyta Skibiński, Robert Szymanowska, Daria Miklaszewski, Andrzej Bednarski, Waldemar Tykarska, Ewa Stasiłowicz, Anna Zalewski, Przemysław |
author_facet | Kilińska, Karolina Cielecka-Piontek, Judyta Skibiński, Robert Szymanowska, Daria Miklaszewski, Andrzej Bednarski, Waldemar Tykarska, Ewa Stasiłowicz, Anna Zalewski, Przemysław |
author_sort | Kilińska, Karolina |
collection | PubMed |
description | The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed. |
format | Online Article Text |
id | pubmed-6278425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62784252018-12-13 The Radiostability of Meropenem Trihydrate in Solid State Kilińska, Karolina Cielecka-Piontek, Judyta Skibiński, Robert Szymanowska, Daria Miklaszewski, Andrzej Bednarski, Waldemar Tykarska, Ewa Stasiłowicz, Anna Zalewski, Przemysław Molecules Article The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed. MDPI 2018-10-23 /pmc/articles/PMC6278425/ /pubmed/30360551 http://dx.doi.org/10.3390/molecules23112738 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kilińska, Karolina Cielecka-Piontek, Judyta Skibiński, Robert Szymanowska, Daria Miklaszewski, Andrzej Bednarski, Waldemar Tykarska, Ewa Stasiłowicz, Anna Zalewski, Przemysław The Radiostability of Meropenem Trihydrate in Solid State |
title | The Radiostability of Meropenem Trihydrate in Solid State |
title_full | The Radiostability of Meropenem Trihydrate in Solid State |
title_fullStr | The Radiostability of Meropenem Trihydrate in Solid State |
title_full_unstemmed | The Radiostability of Meropenem Trihydrate in Solid State |
title_short | The Radiostability of Meropenem Trihydrate in Solid State |
title_sort | radiostability of meropenem trihydrate in solid state |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278425/ https://www.ncbi.nlm.nih.gov/pubmed/30360551 http://dx.doi.org/10.3390/molecules23112738 |
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